Mechanisms on Chronicity of Infectious Diseases from Warm Disease Theory of Pathogen Invading Nutrient and Blood Aspects： Integrating Classical Wisdom with Innovative Perspectives
10.13422/j.cnki.syfjx.20251016
- VernacularTitle:温病“主客交”视角下感染性疾病慢性化机制、经典传承与创新思考
- Author:
Baixue LI
1
;
Hang ZHOU
1
;
Jibin LIU
1
;
Xia LI
1
;
Xiyang LIU
1
;
Haihui LIU
1
;
Peijie WU
1
;
Dong WANG
1
;
Cen JIANG
1
;
Wenjun WU
1
;
Quansheng FENG
1
Author Information
1. School of Basic Medical Sciences， Chengdu University of Traditional Chinese Medicine， Chengdu 610066，China
- Publication Type:Journal Article
- Keywords:
pathogen invading nutrient and blood aspects;
blood collateral of Yin aspect;
infectious diseases;
inheritance of traditional Chinese medicine（TCM） classics;
immune inflammatory response;
tissue repair;
extracellular matrix （ECM） deposit
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(14):60-69
- CountryChina
- Language:Chinese
-
Abstract:
The chronicity of infectious diseases is an important field in the collaborative research of traditional Chinese and Western medicine. The warm disease theory of pathogen invading nutrient and blood aspects in traditional Chinese medicine （TCM） takes the struggle between healthy Qi and pathogenic Qi and cementation of Yin as the core pathogenesis， providing a unique theoretical framework for explaining the common pathology of infectious chronic diseases. This theory originated from Yin-Yang interaction in the Internal Classic and was enriched with WU Youke's theory of intruding pathogen interacting and lingering in blood vessels and YE Tianshi's theory of long-term illness entering collaterals. Combining the theory with modern medical knowledge， our team has condensed the dynamic pathogenesis model of deficiency （nutrient and blood aspects） and excess （pathogen） interacting in the blood collaterals of Yin aspect， the core feature of which is the four-dimensional interactions of cause （pathogen characteristics）， location （three Yin locations of diseases）， nature （deficiency and excess）， and potential （transmission trend）. The common pathology of infectious chronic diseases is reflected in interactions. That is， the interactions between nutrient and blood deficiency （immune exhaustion and metabolic disorder） and pathogen excess （pathogen persistence and fibrous hyperplasia） in the liver collaterals （Jueyin）， kidney collaterals （Shaoyin）， lung collaterals （Taiyin） and other blood collaterals of Yin aspect form the pathological damage characterized by immune inflammatory response-continuous tissue damage with excessive repair. Taking the inheritance and innovative development of classics as the main line， this paper systematically discusses the scientific connotation of the theory of pathogen invading nutrient and blood aspects and the paths of inheritance and innovation and clarifies the original significance of this theory in the chronic development of infectious diseases. Furthermore， taking clinical diseases as an example， this paper reflects the guiding value of this classical theory in the modern diagnosis and treatment of infectious diseases with integrated traditional Chinese and Western medicine and the application potential of this theory in solving complex medical problems through the construction of the innovative paradigm of precise diagnosis and treatment with integrated traditional Chinese and Western medicine.
