Advances in PI3K/AKT/eNOS/NO pathway in repeated low-intensity red light treatment for myopia
10.3980/j.issn.1672-5123.2026.7.19
- VernacularTitle:PI3K/AKT/eNOS/NO信号通路在重复低强度红光治疗近视中的研究进展
- Author:
Hui LI
1
;
Qin ZHU
1
;
Min HU
1
Author Information
1. Kunming Medical University, Kunming 650021, Yunnan Province, China
- Publication Type:Journal Article
- Keywords:
PI3K/AKT axis;
endothelial nitric oxide synthase(eNOS)phosphorylation;
choroidal thickening;
low-intensity red light therapy;
myopia
- From:
International Eye Science
2026;26(7):1222-1227
- CountryChina
- Language:Chinese
-
Abstract:
Myopia has become a growing public health issue globally, characterized by an earlier age of onset and a rising annual incidence rate, particularly among adolescents. Repeated low-intensity red light therapy(RLRL)has gained widespread attention in recent years as an emerging non-invasive intervention, showing promise for controlling myopia. This article examines the role of the PI3K/AKT signaling pathway in RLRL,specifically advances in promoting choroidal thickening via the phosphorylation mechanism of endothelial nitric oxide synthase(eNOS). Choroidal thickening is recognized as a critical part of myopia control. Activation of the PI3K/AKT/eNOS-NO signaling pathway may attenuate axial elongation by enhancing choroidal blood flow and nutrient supply. Although certain basic and clinical studies have supported this mechanism, many unresolved issues still remain, such as the specific mechanisms of RLRL action, its safety, and its applicability in different populations. This article systematically reviews the relevant research progress, aiming to provide a valuable reference for future studies and explore the application prospects of RLRL in myopia prevention and control.
