Research progress on ocular accommodative function in the mechanism of axial elongation
10.3980/j.issn.1672-5123.2026.7.17
- VernacularTitle:眼调节功能在眼轴增长中作用机制的研究进展
- Author:
Jiale DIAO
1
;
Peng WU
1
;
Jiantao REN
1
;
Shuai SHENG
1
;
Xudong HUANG
1
Author Information
1. School of Clinical Medical, Shandong Second Medical University, Weifang 261053, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
accommodative function;
axial elongation;
mechanism of myopia;
myopia
- From:
International Eye Science
2026;26(7):1210-1215
- CountryChina
- Language:Chinese
-
Abstract:
Accommodative dysfunction, particularly accommodative lag, acts as a core hub connecting near work activity to myopic axial elongation. This review thoroughly explores the multidimensional biological mechanisms by which accommodative function drives axial growth. In addition to the classic pathway where hyperopic defocus signals induce retinal-choroidal-scleral biochemical remodeling, two other mechanisms are highlighted: a biomechanical pathway involving direct mechanical traction on the equatorial sclera caused by sustained ciliary muscle contraction, and a neural pathway where abnormal accommodative micro fluctuations degrade retinal image quality, thereby triggering abnormal ocular growth. Based on these comprehensive mechanisms, this paper systematically analyzes the principles of pharmacological(atropine), optical(orthokeratology, defocus lenses), and vision therapy interventions. Myopia progression results from the integrated regulation of optical defocus, mechanical stress, and neural dynamics. Future myopia control should advance toward precise, personalized combination strategies tailored to individual accommodative and genetic profiles.
