Research progress on the clinical application and mechanism of Chaihu jia longgu muli decoction in the treatment of neurological diseases
- VernacularTitle:柴胡加龙骨牡蛎汤治疗神经系统疾病的临床应用及作用机制研究进展
- Author:
Yimeng KONG
1
;
Zhiyong LIU
1
;
Chengsi DUAN
1
;
Lanyun SHI
1
;
Meina ZHAO
1
;
Mengyuan ZHANG
1
;
Chen YANG
1
Author Information
1. The Second Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
Chaihu jia longgu muli decoction;
neurological diseases;
clinical application;
mechanism of action
- From:
China Pharmacy
2026;37(11):1515-1520
- CountryChina
- Language:Chinese
-
Abstract:
Neurological diseases have high morbidity and disability rates， posing a severe threat to human health. Cli nical manifestations include motor， sensory， cognitive and conscious disorders. Chaihu jia longgu muli decoction is derived from Treatise on Febrile Diseases ， with the effects of harmonizing Shaoyang， activating Yang and clearing heat， and tranquilizing the mind. This paper systematically reviews the research progress in clinical application and mechanism of Chaihu jia longgu muli decoction in the field of neurological diseases. It has been found that the decoction shows favorable efficacy in various neurological diseases such as insomnia， depression， epilepsy， vertigo， migraine and vascular dementia. The specific mechanisms are related to regulating neurotransmitter levels， repairing neuronal function， alleviating neuroinflammation， improving mitochondrial dysfunction and regulating intestinal flora. In the future， standardized prospective follow-up cohorts should be established， and core outcome indicators should be clearly defined to strengthen the evidence base. Furthermore， multidisciplinary research should be leveraged to expand the therapeutic value of Chaihu jia longgu muli decoction in the management of neurological diseases.
