Treatment of Infection-Related Type 1 Diabetes Mellitus from the Perspective of Latent Pathogen and Dryness Disorder
10.13288/j.11-2166/r.2026.12.014
- VernacularTitle:从伏邪燥病角度论治感染相关1型糖尿病
- Author:
Zhaobo WANG
1
;
Yingying YANG
1
;
Jia WANG
1
;
Linhua ZHAO
1
;
Xiaolin TONG
1
Author Information
1. Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing，100053
- Publication Type:Journal Article
- Keywords:
type 1 diabetes mellitus;
infection;
latent pathogen;
dryness disorder;
targeted differentiation treatment
- From:
Journal of Traditional Chinese Medicine
2026;67(12):1329-1333
- CountryChina
- Language:Chinese
-
Abstract:
Infection is an important trigger for the initiation of pancreatic islet autoimmunity in type 1 diabetes mellitus （T1DM）. From the perspective of latent pathogen and dryness disorder， this study analyzes the core pathogenesis and dynamic evolution of T1DM in the subclinical and clinical stages. Combined with the T1DM "constraint， heat， deficiency， damage" state and target differentiation and treatment theory， the course of infection-induced T1DM is divided into three stages， including latent dryness， dry-heat and collateral damage. The "latent dryness" stage corresponds to the subclinical phase of T1DM， while the "dry-heat" stage corresponds to the clinical phase， and the "collateral damage" stage corresponds to the phase in which chronic complications develop. Treatment principles include supplementing deficiency and dispelling pathogen during the "latent dryness" stage， clearing heat and moistening dryness in the "dry-heat" stage， and dissolving stasis and unblocking collaterals in the "collateral damage" stage. Furthermore， syndrome-targeted and target-directed therapeutic modifications were made according to T1DM-related autoimmune activity， metabolic comorbidities， and vascular comorbidities， providing a reference for clinical management of T1DM.
