Immune-Inflammatory Mechanisms and Traditional Chinese Medicine Intervention Strategies of Colorectal Cancer Cachexia Based on the "Reinforcing Healthy Qi and Dispelling Pathogen" Theory
10.13288/j.11-2166/r.2026.12.005
- VernacularTitle:基于扶正祛邪理论探讨结直肠癌恶病质的免疫-炎症调控机制及干预策略
- Author:
Zhenming XIE
1
;
Wenyu WU
2
;
Wenqi HUANG
1
;
Huili SHUI
1
;
Bing YANG
1
;
Dongxin TANG
1
Author Information
1. Guizhou University of Traditional Chinese Medicine，Guiyang，550025
2. The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
cachexia;
reinforcing healthy qi and dispelling pathogen;
immune reaction;
inflammation
- From:
Journal of Traditional Chinese Medicine
2026;67(12):1267-1271
- CountryChina
- Language:Chinese
-
Abstract:
This paper explores the immune-inflammatory regulatory mechanism of colorectal cancer cachexia and corresponding traditional Chinese medicine （TCM） intervention strategies based on the TCM theory of reinforcing healthy qi and dispelling pathogenen. It is proposed that depletion of healthy qi is the root cause of colorectal cancer cachexia， while cancer toxins exuberance is the symptomatic manifestation of the disease， and failure of the spleen and stomach is the core pathogenesis. In terms of treatment， a TCM treatment system is constructed based on the principles of reinforcing healthy qi to consolidate the foundation and regulate immunity， and dispelling pathogen to remove toxins and alleviate inflammation. The system clarifies the healty qi-reinforcing method as fortifying spleen and boosting qi to enhance immune function， and nourishing blood and enriching yin to consolidate yin essence and healthy qi. It also emphasizes the pathogen-dispelling method as clearing heat and removing toxins to regulate the secretion of inflammatory cytokines， and promoting blood circulation and resolving stasis to improve the immune microenvironment and microcirculation. This therapeutic approach may provide valuable insights for TCM interventions in colo-rectal cancer cachexia.
