Research Progress on Animal Models of Systemic Sclerosis with Microvascular Involvement

VernacularTitle:系统性硬化症合并微血管受累动物模型研究进展
Author: Haochen HUANG ¹ ; Lingling ZHANG ² ; Dong XU ¹
Author Information

1. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;
2. Department of Rheumatology and Clinical Immunology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China;
Publication Type:Review
Keywords: systemic sclerosis; microvascular involvement; animal model
From: Medical Journal of Peking Union Medical College Hospital 2026;17(3):834-841
CountryChina
Language:Chinese
Abstract:
The early angiopathy of systemic sclerosis (SSc) is a key hub connecting inflammation and fibrosis. The animal models that simulate the pathological characteristics of SSc are of great significance to study the etiology, pathogenesis and treatment of SSc with vascular involvement. This review of the characteristics of different animal models of SSc with vascular involvement provides a reference for relevant researchers to select appropriate models in the process of exploring the pathogenesis of SSc with vascular involvement.