A panel study on association of short-term air pollution exposure and peripheral blood microparticles in healthy adults

Bin ZHANG; Xinghou HE; Jiahui LIU; Xuyang SHAN; Yan FANG; Huiying XU; Erlu ZHAO; Shengcong LIU; Hongbing XU; Jianping LI; Wei HUANG

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A panel study on association of short-term air pollution exposure and peripheral blood microparticles in healthy adults

VernacularTitle:短期空气污染物暴露与健康成人外周血微粒的定组研究
Author: Bin ZHANG ¹ ; Xinghou HE ¹ ; Jiahui LIU ¹ ; Xuyang SHAN ¹ ; Yan FANG ¹ ; Huiying XU ¹ ; Erlu ZHAO ¹ ; Shengcong LIU ² ; Hongbing XU ³ ; Jianping LI ² ; Wei HUANG ¹
Author Information

1. .
2. Division of Cardiology, Peking University First Hospital, Beijing 100034, China.
3. Institute of Radiological Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China;State Key Laboratory of Advanced Medical Materials and Devices, Chinese Academy of Medical Sciences Tianjin Institutes of Health Science, Tianjin 301600, China.
Publication Type:Selectedarticle
Keywords: air pollution; microparticle; inflammation; cardiovascular health; healthy adult
From: Journal of Environmental and Occupational Medicine 2026;43(1):1-7
CountryChina
Language:Chinese
Abstract: Background Microparticles (MPs) are one of the main medium of inflammatory reaction with an important role in atherosclerotic progression. Studies on association of air pollution exposure and levels of peripheral blood MPs are limited among human. Objective To evaluate the effects of short-term exposure to air pollution on levels of peripheral blood MPs. Method A panel of 73 healthy adults was followed with 4 repeated follow-ups in Beijing, China, from November 2014 to January 2016. During each visit, we collected questionnaire information, fasting venous blood, urine, and exposures to fine particulate matter (PM_2.5), black carbon, nitric oxide, nitrogen dioxide, nitrogen oxide, sulfur dioxide, carbon monoxide, and ozone. We used linear mixed-effect models to analyze associations of air pollution exposure with levels of total MPs (TMPs) and MPs derived from various cells. Stratified analysis was conducted by levels of C-reactive protein (CRP) and malondialdehyde (MDA). Results The results showed significant associations between air pollution exposure and peripheral blood TMPs at 2 h-6 d prior to the follow-ups (P<0.05), while no statistical associations were found for MPs derived from different cell types. Significant increases in TMPs of 7.8% (95%CI: 0.7%, 15.3%) and 14.3% (95%CI: 2.8%, 27.2%) were observed with each interquartile range (IQR) increase in PM_2.5 (IQR=64.9 μg·m⁻³) at prior 18 h and NO (IQR=40.5 μg·m⁻³) at prior 48 h. Among participants with low levels of CRP and MDA, significantly positive associations were observed between air pollution exposure and levels of TMPs (P<0.05). Conclusion Short-term exposure to air pollution is significantly associated with increased levels of circulating MPs in healthy adults, and in people with lower systemic inflammation, peripheral blood MPs levels are more easily affected after exposure to air pollutants.