Association of polychlorinated biphenyl exposure with platelet parameters across different glycemic states: The moderating role of a healthy lifestyle

Zhuo CHEN; Huilin LOU; Taimeng CHEN; Fangyuan LIN; Xueyan WU; Yao GUO; Haoran XU; Mengke CHENG; Peihan CHEN; Yilin ZHOU; Zhenxing MAO; Xin TANG

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Association of polychlorinated biphenyl exposure with platelet parameters across different glycemic states: The moderating role of a healthy lifestyle

VernacularTitle:不同糖代谢状态下多氯联苯暴露与血小板参数的关联及健康生活方式的调节作用
Author: Zhuo CHEN ¹ ; Huilin LOU ² ; Taimeng CHEN ² ; Fangyuan LIN ² ; Xueyan WU ² ; Yao GUO ² ; Haoran XU ² ; Mengke CHENG ² ; Peihan CHEN ² ; Yilin ZHOU ² ; Zhenxing MAO ² ; Xin TANG ²
Author Information

1. Henan Institute of Food and Salt Inspection (Henan Provincial Supervision and Inspection Center for Cereals, Oils and Feed Quality), Zhengzhou, Henan 450003, China.
2. Department of Epidemiology and Biostatistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, China.
Publication Type:Selectedarticle
Keywords: polychlorinated biphenyl; platelet parameter; glycemic state; healthy lifestyle; moderating effect
From: Journal of Environmental and Occupational Medicine 2026;43(5):535-541
CountryChina
Language:Chinese
Abstract: Background Platelet parameters are important indicators of cardiovascular risk, and environmental pollutants such as polychlorinated biphenyls (PCBs) may impair platelet function through oxidative stress. Objective To investigate the differential effects of single and mixed exposure to PCBs on platelet parameters among individuals with normal glucose tolerance (NGT), impaired fasting glucose (IFG), and type 2 diabetes mellitus (T2DM), and to evaluate the potential modifying role of a healthy lifestyle. Methods This study included 2249 participants (including 707 with NGT, 759 with IFG, and 783 with T2DM). Plasma PCB concentrations were measured using triple quadrupole gaschromatography-tandem mass spectrometry. Generalized linear regression was used to assess the associations between individual PCB congeners and platelet parameters. Quantile g-computation (QGC) and Bayesian kernel machine regression (BKMR) models were used to evaluate the overall effects of PCBs mixture exposure on platelet parameters across different glycemic states, as well as its interaction with healthy lifestyle score (HLS). Results Generalized linear regression analyses showed significant differences in the effects of PCBs on platelet parameters across different glycemic states (P<0.05). After adjusting for confounders, PCBs mixture exposure was significantly associated with lower platelet counts (PLT) in individuals with NGT (b=−10.60, 95%CI: −16.48, −4.71) and IFG (b=−12.91, 95%CI: −18.90, −6.92), whereas no significant association was observed in individuals with T2DM (P=0.051). Mean platelet volume (MPV) and platelet-large cell ratio (P-LCR) increased significantly with higher PCBs exposure levels across all three groups (P<0.05). BKMR analysis showed a positive association between PCBs mixture exposure and P-LCR, with the strongest association observed in the NGT group. Furthermore, a significant interaction was observed between HLS and PCBs mixture exposure, and a higher HLS attenuated the effects of PCBs on P-LCR. Conclusion Glycemic glycemic states may modify the effects of PCBs on platelets. Individuals with NGT appear more sensitive to PCBs exposure, whereas the T2DM state may attenuate this effect. Moreover, healthy lifestyles, including not smoking, moderate alcohol consumption, maintaining moderate-to-high physical activity, a healthy diet, and an appropriate body mass index (BMI), may mitigate the adverse effects of most PCBs on platelet parameters.