A case report of severe hemolysis associated with high-dose IVIG in a child
10.13303/j.cjbt.issn.1004-549x.2026.05.015
- VernacularTitle:一例儿童大剂量IVIG相关严重溶血病例报告
- Author:
Xiaohong JIN
1
;
Meikun HU
1
;
Mengxing LYU
1
;
Kexuan QU
1
Author Information
1. Kunming Children's Hospital, Kunming, Yunnan 650228, China
- Publication Type:Journal Article
- Keywords:
children;
severe pneumonia;
intravenous human immunoglobulin;
adverse reactions of hemolysis;
drug-induced IgG antibodies
- From:
Chinese Journal of Blood Transfusion
2026;39(5):677-681
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To report severe hemolytic adverse reactions caused by intravenous infusion of human immunoglobulin (IVIG) in a child, and to alert clinical staff to be aware of IVIG-associated hemolytic reactions to ensure transfusion safety in pediatric populations. Methods: A retrospective analysis was conducted on a case of severe hemolytic reaction following high-dose IVIG infusion in a pediatric patient with severe pneumonia. Results: Following high-dose IVIG infusion, severe hemolytic adverse reactions developed, clinically manifesting as decreased hemoglobin, progressively elevated bilirubin and lactate dehydrogenase (LDH), and gradual hepatomegaly. IgG antibodies were detected in the patient's erythrocytes and plasma. Conclusion: When patients passively acquire IgG antibodies through IVIG infusion, timely monitoring of antibody titers in vivo is critical. For subsequent transfusions, red blood cell products that lack the corresponding antigens should be selected to mitigate hemolysis. Clinicians should remain vigilant against rare but severe hemolytic adverse reactions.
