Exploring the non-laboratory factors influencing coagulation factor Ⅷ and fibrinogen in fresh frozen plasma
10.13303/j.cjbt.issn.1004-549x.2026.05.012
- VernacularTitle:影响新鲜冰冻血浆中凝血因子Ⅷ和纤维蛋白原的非检验因素
- Author:
Changjun SHI
1
;
Danhui LI
1
;
Xiuqin ZHAO
2
Author Information
1. Xuzhou Red Cross Blood Center, Xuzhou 221000, China
2. Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China
- Publication Type:Journal Article
- Keywords:
fresh frozen plasma (FFP);
fibrinogen (Fib);
coagulation factor Ⅷ(FⅧ);
blood quality control
- From:
Chinese Journal of Blood Transfusion
2026;39(5):656-666
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the non-laboratory factors affecting fibrinogen (Fib) levels, coagulation factor Ⅷ (FⅧ) activity, and the quality inspection pass rate of fresh frozen plasma (FFP), so as to provide scientific guidance for its preparation, storage, clinical transfusion, and quality inspection. Methods: 1) Twenty bags of B-type Rh(D) positive fresh frozen plasma were randomly selected, and FⅧ activity and Fib levels were determined at different storage times. The data were analyzed using the paired t-test, one-way repeated-measures ANOVA, and the Bonferroni post-hoc test. 2) The detection data of FⅧ activity in fresh frozen plasma from January 2022 to September 2025 were retrospectively analyzed using Welch's ANOVA, multiple comparison tests, chi-square test, rank-sum test, Fisher's exact test and other statistical methods. Results: 1) There were statistically significant differences in FⅧ activity at different storage times (P<0.05), while no significant difference was found in Fib levels (P>0.05). FⅧ activity gradually decreased from 0 h to 48 h and remained stable from 48 h to 120 h. 2) There was no statistically significant difference in FⅧ activity between different genders (P>0.05). In contrast, significant differences were observed across age groups (P<0.05), with FⅧ activity rising markedly in individuals aged over 40. Significant differences in FⅧ activity were also identified among different blood groups (P<0.05), with type O showing the lowest activity and type AB the highest. No significant difference in the pass rate of FFP was found between genders (P>0.05). No statistically significant difference in pass rates was observed across different age groups when stratified by blood type (P>0.05), whereas significant differences in pass rates among different blood types were identified when stratified by age (P<0.05). These differences were found in the 29-39 years and 40-50 years age groups. Conclusion: 1) FⅧ activity in FFP declines rapidly within 48 hours and should be transfused as early as possible. From 48 to 120 hours, FⅧ activity tends to stabilize and remains above 50%, still meeting the requirements for hemostasis. 2) Blood type and age are influencing factors of FⅧ activity in FFP, with the activity ranked as type AB>type B>type A>type O, blood donors aged over 40 show higher FⅧ activity. Gender is not a factor affecting FⅧ activity, although females have higher levels than males. The correlation between blood group and the quality-inspection pass rate of FFP is affected by age stratification. Differences among blood groups and age groups should be considered during the quality control of blood products.
