Summary of the best evidence for the management of gastrointestinal graft-versus-host disease after hematopoietic stem cell transplantation
10.13303/j.cjbt.issn.1004-549x.2026.05.006
- VernacularTitle:造血干细胞移植并发胃肠道移植物抗宿主病管理的最佳证据总结
- Author:
Fangchen GU
1
;
Yongqin GE
1
;
Huijuan MEI
2
;
Yin LU
1
;
Xiaming ZHU
1
Author Information
1. Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
2. School of Nursing, Soochow University, Suzhou 215006, China
- Publication Type:Journal Article
- Keywords:
hematopoietic stem cell transplantation;
graft-versus-host disease;
gastrointestinal tract;
summary of evidence;
evidence-based nursing
- From:
Chinese Journal of Blood Transfusion
2026;39(5):610-618
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To summarize the best evidence for the management of patients with gastrointestinal graft-versushost disease after hematopoietic stem cell transplantation, and provide evidence-based references for clinical nursing work. Methods: A systematic search was conducted for relevant evidence on the management of patients with gastrointestinal graft-versus-host disease after hematopoietic stem cell transplantation from domestic and foreign databases, as well as websites of blood and bone marrow transplantation related societies. The search period was from the establishment of the database until February 2026. Results: After screening, a total of 19 articles were included, encompassing 3 clinical decisions, 1 recommended practice, 4 guidelines, 7 expert consensuses, and 4 evidence summaries. Twenty-five pieces of best evidence were summarized across 8 aspects: multidisciplinary collaboration, influencing factors, assessment and monitoring, diagnostic differentiation, symptom management, dietary nutrition, medication guidance, and health education. Conclusion: Summarizing the relevant evidence on the management of patients with gastrointestinal graft-versus-host disease after hematopoietic stem cell transplantation can provide evidence-based support for clinical medical staff, and it is recommended to apply it in combination with clinical practice and patient wishes.
