Mechanism of the interaction between immunosuppressive therapy and intestinal microflora after liver transplantation

Yan WANG; Yufeng LIU; Haiyang ZHANG; Zhiwei ZHANG; Jun XU; Zhiyong LAI

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Mechanism of the interaction between immunosuppressive therapy and intestinal microflora after liver transplantation

VernacularTitle:肝移植术后免疫抑制剂治疗与肠道微生态的相互作用及机制
Author: Yan WANG ¹ ; Yufeng LIU ² ; Haiyang ZHANG ³ ; Zhiwei ZHANG ¹ ; Jun XU ⁴ ; Zhiyong LAI ⁵
Author Information

1. The First Clinical Medical College of Shanxi Medical University， Taiyuan 030001， China
2. Microbiological Laboratory of Ophthalmology， Shanxi Eye Hospital， Taiyuan 030002， China
3. Department of Gastroenteropancreatic， Hernia and Abdominal Wall Surgery， Shanxi People’s Hospital， Taiyuan 030001， China
4. Department of Hepatobiliary Surgery and Liver Transplantation Center， The First Hospital of Shanxi Medical University， Taiyuan 030001， China
5. Department of Biliopancreatic Surgery， The First Hospital of Shanxi Medical University， Taiyuan 030001， China
Publication Type:Review
Keywords: Liver Transplantation; Immunosuppressive Agents; Gastrointestinal Microbiome
From: Journal of Clinical Hepatology 2026;42(4):980-986
CountryChina
Language:Chinese
Abstract: The application of immunosuppressants has significantly reduced the incidence rate of rejection reaction after liver transplantation， but the clinical efficacy of immunosuppressants is greatly affected by individual differences between patients. This article systematically reviews the recent research advances in the interaction between immunosuppressants and gut microbiota， with a focus on the regulatory role and mechanism of intestinal microflora communities on the efficacy of immunosuppressants. Studies have shown that intestinal microbiome is one of the key factors influencing the efficacy of immunosuppressive therapy after liver transplantation. This review aims to provide a theoretical basis for in-depth research in this field and provide new insights for developing individualized immunosuppressive treatment regimens based on the regulation of intestinal microflora.