Roles and mechanism of bile acids and gut microbiota in primary biliary cholangitis
- VernacularTitle:胆汁酸与肠道菌群在原发性胆汁性胆管炎发生发展中的作用及机制
- Author:
Mengyao WU
1
;
Jiayin PAN
1
;
Rong DING
1
;
Jinyu LI
1
;
Wenlin TAI
1
Author Information
- Publication Type:Review
- Keywords: Primary Biliary Cholangitis; Bile Acids and Salts; Gastrointestinal Microbiome
- From: Journal of Clinical Hepatology 2026;42(4):957-964
- CountryChina
- Language:Chinese
- Abstract: Primary biliary cholangitis （PBC） is a cholestatic autoimmune liver disease characterized by the injury of small intrahepatic bile ducts， and at present， the pathogenesis of PBC remains unclear. Recent studies have shown that bile acid metabolism disorder and gut microbiota imbalance play a key role in the development and progression of PBC， and they form a complex and dynamic interaction network via the “gut-liver axis” and regulate core physiopathological processes such as immune response， metabolic homeostasis， and inflammatory response in a synergistic manner. This article systematically elaborates on the abnormal features of bile acid metabolism and gut microbiota in PBC， discusses their synergistic mechanisms in PBC， and then proposes a combined strategy of targeting bile acid receptors and modulating gut microbiota， in order to overcome the limitations of current treatment modalities and provide new insights and directions for the clinical management of PBC.
