Metabolic-dysfunction and alcohol-associated liver disease： A new concept and recent advances

VernacularTitle:代谢功能障碍与酒精相关性肝病：新概念与新进展
Author: Rutao LIN ¹ ; Fei XU ¹ ; Xin XIN ¹ ; Yiyang HU ¹ ; Qin FENG ¹
Author Information

1. Institute of Liver Diseases， Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China
Publication Type:Review
Keywords: Metabolic-Dysfunction and Alcohol-Associated Liver Disease; Metabolic Dysfunction-Associated Fatty Liver Disease; Alcohol-Related Liver Disease
From: Journal of Clinical Hepatology 2026;42(4):950-956
CountryChina
Language:Chinese
Abstract: In 2023， multiple international societies proposed the concept of metabolic-dysfunction and alcohol-associated liver disease （MetALD） to characterize patients with steatotic liver disease who exhibit metabolic dysfunction and consume alcohol at a moderate level. In recent years， the evidence system in this field has been constantly developed and improved. This article reviews the latest research advances in MetALD from the aspects of background， definition， epidemiological characteristics， natural history， clinical phenotype， diagnostic and assessment methods， and treatment regimens， as well as the directions for future investigation.