The regulatory role of microRNA in the progression from metabolic dysfunction-associated fatty liver disease to hepatocellular carcinoma
- VernacularTitle:微RNA在代谢相关脂肪性肝病向肝细胞癌进展中的调控作用
- Author:
Jiali XIE
1
;
Yaonan LIU
1
;
Rui ZHAO
1
Author Information
- Publication Type:Review
- Keywords: Metabolic Dysfunction-Associated Fatty Liver Disease; Carcinoma， Hepatocellular; MicroRNAs
- From: Journal of Clinical Hepatology 2026;42(4):943-949
- CountryChina
- Language:Chinese
- Abstract: Metabolic dysfunction-associated fatty liver disease （MAFLD） is the main cause of chronic liver disease around the world and can eventually lead to hepatocellular carcinoma. This article describes the evolution of the definition of MAFLD， the epidemiological burden of MAFLD， and the biosynthesis and biological functions of microRNA （miRNA）， as well as the important role of various types of miRNA in the progression of MAFLD by regulating the processes such as lipid metabolism， inflammation and liver fibrosis， oxidative stress， endoplasmic reticulum stress， and glycolysis. This article also evaluates the application prospect of miRNA as diagnostic biomarkers and therapeutic targets. It is pointed out that although existing studies have shown that miRNA plays an important role in the progression of MAFLD， there are still challenges in clinical translation， and large-scale studies should be conducted in the future to clarify the practical value of miRNA in MAFLD diagnosis and treatment， thereby providing new ways for precision medicine.
