Metabolic dysfunction-associated fatty liver disease with different clinical phenotypes： Pathogenesis and strategies for integrated traditional Chinese and Western medicine treatment

Wenxia ZHAO; Lei GAO; Xinju CHEN; Yuanyuan ZHENG; Sutong LIU; Lihui ZHANG; Qing ZHAO; Chenlu ZHAO

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Metabolic dysfunction-associated fatty liver disease with different clinical phenotypes： Pathogenesis and strategies for integrated traditional Chinese and Western medicine treatment

VernacularTitle:不同临床表型代谢相关脂肪性肝病的发病机制及中西医结合治疗策略
Author: Wenxia ZHAO ¹ ; Lei GAO ² ; Xinju CHEN ¹ ; Yuanyuan ZHENG ¹ ; Sutong LIU ¹ ; Lihui ZHANG ¹ ; Qing ZHAO ¹ ; Chenlu ZHAO ¹
Author Information

1. Spleen， Stomach and Hepatobiliary Department， The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450000， China
2. School of Basic Medical Sciences， Guangzhou University of Chinese Medicine， Guangzhou 510006， China
Publication Type:Review
Keywords: Metabolic Dysfunction-Associated Fatty Liver Disease; Obesity; Hyperlipidemias; Diabetes Mellitus， Type 2; Postmenopause; Hepatitis B， Chronic
From: Journal of Clinical Hepatology 2026;42(4):930-937
CountryChina
Language:Chinese
Abstract: Metabolic dysfunction-associated fatty liver disease （MAFLD） is a chronic metabolic liver disorder with complex etiologies. Different clinical phenotypes of MAFLD （such as obesity， hyperlipidemia， type 2 diabetes mellitus， the postmenopausal state， and chronic hepatitis B） have different mechanisms of action in the development and progression of MAFLD， leading to high heterogeneity in its clinical progression and prognosis. This article systematically reviews the pathogeneses and clinical features of the above five clinical phenotypes of MAFLD and elaborates on the corresponding individualized diagnosis and treatment regimens integrating traditional Chinese medicine and Western medicine， in order to provide a reference for clinical practice and improve clinical diagnosis and treatment.