Traditional Chinese Medicine Prevention and Treatment of Ischemic Stroke by Intervening in Brain Microvascular Endothelial Cells： A Review
10.13422/j.cnki.syfjx.20251940
- VernacularTitle:中药干预脑微血管内皮细胞防治缺血性脑卒中的研究进展
- Author:
Wenxiu QIN
1
;
Gang WEI
1
;
Qingjie KONG
1
;
Huiying SUN
1
;
Junfeng XU
1
;
Ying GAO
1
;
Jian YANG
1
Author Information
1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine（TCM）， Tianjin 300381，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
brain microvascular endothelial cells;
blood-brain barrier;
ischemic stroke;
cerebral ischemia-reperfusion injury
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(13):336-346
- CountryChina
- Language:Chinese
-
Abstract:
The blood-brain barrier （BBB） is a physical and biochemical barrier that precisely regulates brain homeostasis and plays a central role in controlling the transport of endogenous and exogenous drugs and related metabolites across the blood-brain interface. These functions of the BBB are mediated by its major components， including brain microvascular endothelial cells （BMECs）， tight junction protein complexes， and influx and efflux transporter proteins. One of the pathological features of ischemic stroke （IS） is BBB disruption， which plays an important role in the development of post-stroke brain injury and subsequent neurological dysfunction. Therefore， given the increasing incidence of IS， there is an urgent need to develop new therapeutic strategies to prevent BBB dysfunction and thereby protect injured brain tissue after IS. This study describes the pathological mechanisms by which BMEC injury after IS leads to BBB dysfunction and elucidates the association between BMECs and IS， including the regulation of apoptosis， autophagy， inflammatory responses， oxidative stress， neurotoxic effects， and cerebral edema. In addition， this article summarizes Chinese herbal medicines that may prevent and treat IS by targeting BMECs. These include monomeric compounds and single herbs such as flavonoids， glycosides， phenols， phthalides， terpenoids， and Styrax. Traditional Chinese medicine （TCM） compound formulas and preparations include oral formulations such as Buyang Huanwu decoction， Sailuotong， Naoxintong capsules， Dandeng Tongnao capsules， and Shexiang Tongxin dropping pills， as well as injectable preparations such as Tongluo Jiunao injection， Xingnaojing injection， Danshen polyphenolic acid for injection， Yiqi Fumai injection， and Shuxuetong injection. This study aims to explore the protective effects of TCM against IS through targeted regulation of BMEC function， providing new insights into the mechanisms of IS and endovascular therapeutic strategies.
