Traditional Chinese Medicine Regulates VEGF Signaling Pathway for Anti-angiogenic Intervention in Preneoplastic Breast Cancer： A Review
10.13422/j.cnki.syfjx.20251524
- VernacularTitle:中医药调控VEGF信号通路抗血管生成干预乳腺癌癌前病变的研究进展
- Author:
Huikun BAI
1
;
Min HUANG
2
;
Benfa LI
1
;
Rong ZHAO
1
;
Zhuoling LI
1
;
Dongdong ZHAO
1
;
Na YANG
1
;
Awei BI
1
;
Yun GAN
1
Author Information
1. The First Clinical Medical School of Yunnan University of Chinese Medicine， Kunming 650500，China
2. The First Affiliated Hospital of Yunnan University of Chinese Medicine， Kunming 650021，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
preneoplastic breast cancer;
vascular endothelial growth factor（VEGF）;
angiogenesis;
research advances
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(13):295-302
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer prevention and treatment have become major issues that urgently need to be addressed in the field of global public health. As a key pathological transitional stage in the progression of breast cancer， preneoplastic breast cancer （PBC） carries a significant risk of clinical transformation. Effective intervention in the progression of PBC is of great clinical significance in preventing the occurrence of breast cancer. Pathological studies have shown that abnormal angiogenesis is a key mechanism driving the transformation of PBC into breast cancer. Vascular endothelial growth factor （VEGF）， as a core regulatory molecule that promotes angiogenesis， plays a pivotal role in this process. The malignant transformation of PBC is closely associated with the abnormal activation of the VEGF-mediated pro-angiogenic network. Although modern medicine has achieved certain therapeutic effects through surgery and endocrine therapy， clinical limitations such as invasiveness， drug resistance， and adverse reactions still exist. Recent studies have demonstrated that the VEGF signaling system mediates the phosphatidylinositol 3-kinase-protein kinase B （PI3K/Akt） signaling pathway and the mitogen-activated protein kinase （MAPK） pathway. In addition， the hypoxia-inducible factor-1α （HIF-1α）/VEGF signaling pathway and the delta-like ligand 4 （DLL4）/Notch receptor 1 （Notch1） signaling pathway， together with other pathways， form a complex regulatory network that plays a central role in angiogenesis during PBC. Traditional Chinese medicine （TCM）， characterized by multi-component synergy， multi-pathway regulation， and high safety， demonstrates significant advantages in inhibiting pathological angiogenesis and blocking PBC progression by targeting the VEGF signaling pathway. From the perspective of VEGF pathway regulation， this paper systematically reviews the latest research progress on TCM in inhibiting angiogenesis and intervening in PBC， and discusses its mechanisms and application value in the early prevention and treatment of PBC， with the aim of providing references for optimizing clinical intervention strategies for PBC.
