miRNA Regulatory Network and Traditional Chinese Medicine Intervention in Asthma and Cough Variant Asthma from Perspective of Airway Microenvironment： A Review
10.13422/j.cnki.syfjx.20260265
- VernacularTitle:哮喘与咳嗽变异性哮喘基于气道微环境视角下的miRNA调控网络及中医药干预研究进展
- Author:
Lisha LU
1
;
Wen QIN
1
;
Mingshu YANG
1
;
Xiaochang WANG
1
;
Lujia LIU
2
;
Youpeng WANG
2
Author Information
1. Graduate School，Heilongjiang University of Chinese Medicine，Harbin 150040，China
2. The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150001，China
- Publication Type:Journal Article
- Keywords:
airway microenvironment;
asthma;
cough variant asthma（CVA）;
micro ribonucleic acid（miRNA）;
signaling pathway;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(13):282-294
- CountryChina
- Language:Chinese
-
Abstract:
Asthma and cough variant asthma （CVA） are both chronic heterogeneous diseases characterized by airway microenvironment homeostasis disruption as their core pathological basis. In recent years， micro ribonucleic acid （miRNA）， as core post-transcriptional regulators， have been shown to finely modulate multiple critical signaling pathways， including Janus kinase/signal transducer and activator of transcription （JAK/STAT）， nuclear factor-κB （NF-κB）， transforming growth factor-β/Smad （TGF-β/Smad）， and phosphoinositide 3-kinase/protein kinase B （PI3K/Akt）， as well as various pathological processes such as airway epithelial barrier restoration， type 1 helper T cell（Th1）/Th2 immune balance， M1/M2 macrophage polarization， airway smooth muscle cell function， and airway hyperresponsiveness. miRNAs play a pivotal role in maintaining and disrupting airway microenvironment homeostasis. Based on recent Chinese and international literature， a logical framework centered on "airway microenvironment homeostasis disruption， miRNA regulation， and microenvironment restoration" was constructed. From the perspective of the airway microenvironment， the therapeutic roles of miRNA in asthma and CVA were systematically summarized， and the cascade regulatory mechanisms of miRNA throughout the entire disease course were elucidated. The hub miRNA was identified， and research progress on traditional Chinese medicine intervention strategies was explored. Furthermore， current clinical studies on RNA therapeutics and traditional Chinese medicine in achieving multi-target and multi-pathway integrated treatment by modulating miRNA were analyzed. The value of miRNA as biomarkers for diagnosis， phenotyping， and prognosis assessment， as well as the potential and application prospects of miRNA mimics and antagonists in precision therapy， were summarized， with the ultimate goal of advancing precision therapy for asthma and CVA.
