Experimental Research and Clinical Application of Shenling Baizhusan in Gastric Ulcer Treatment： A Review
10.13422/j.cnki.syfjx.20251797
- VernacularTitle:参苓白术散治疗胃溃疡的实验研究与临床应用研究进展
- Author:
Changyue SUN
1
;
Hua ZHANG
2
;
Yuwei ZHU
1
;
Qian LI
2
;
Xiaowei ZHONG
3
;
Xiaoping ZHANG
4
;
Xiaofan CHEN
1
Author Information
1. Integrated Traditional Chinese and Western Medicine First level Discipline Platform，Jiangxi University of Chinese Medicine，Nanchang 330000，China
2. School of Pharmacy，Jiangxi University of Chinese Medicine，Nanchang 330000，China
3. Innovation Base Hospital，Jiangxi University of Chinese Medicine，Nanchang 330000，China
4. Affiliated Hospital of Jiangxi University of Chinese Medicine，Nanchang 330000，China
- Publication Type:Journal Article
- Keywords:
gastric ulcer;
Shenling Baizhu San;
clinical application;
pharmacological action;
experimental research
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(13):271-281
- CountryChina
- Language:Chinese
-
Abstract:
Gastric ulcer （GU） is a high-incidence digestive system disease characterized pathologically by disruption of gastric mucosal integrity， with clinical features including a prolonged course and periodic recurrence. Modern medicine attributes its pathogenesis to the dynamic imbalance between aggressive and defensive factors，while traditional Chinese medicine （TCM） posits its development as closely linked to spleen deficiency. Current therapies combining acid suppressants and antibiotics face challenges such as high recurrence rates，poor mucosal healing，and adverse drug reactions. Long-term use may induce metabolic disturbances like hypergastrinemia and reduced intestinal microbiota diversity. Therefore，exploring safer and longer-lasting therapeutic strategies has become a critical focus. TCM has extensive clinical experience and unique advantages in GU prevention and treatment. Studies demonstrate that the classic formula Shenling Baizhu San exhibits therapeutic properties of "invigorating spleen and tonifying Qi to restore physiological balance and eliminating dampness and regulating middle energizer to unblock Qi movement"， enabling a holistic approach targeting both symptoms and root causes in GU with spleen deficiency as the core pathology by suppressing aggressive factors and strengthening defensive factors. Experimental research reveals its mechanisms involve enhancing the physicochemical barrier of the mucus layer，repairing epithelial barriers and microcirculation，modulating gastric acid secretion and gastrointestinal motility，and regulating microecological barriers and mucosal immunity. Clinical evidence confirms its synergistic effects in promoting ulcer healing，improving Helicobacter pylori eradication rates，and reducing recurrence risks. This review examined the etiology and pathogenesis of GU and systematically evaluated Shenling Baizhu San from three perspectives-clinical application，pharmacological effects， and experimental research-to provide insights for optimizing integrated traditional Chinese and Western medicine protocols and expanding its clinical applications.
