Biological functions of SMYD5 and its role in disease
10.19405/j.cnki.issn1000–1492.2026.04.026
- VernacularTitle:SMYD5的生物学功能及其在疾病中的作用
- Author:
Fangfang ZHANG
1
;
Haodan LIU
1
;
Ruirui YANG
2
;
Xuan LI
1
;
Changli WANG
1
;
Guangbin YE
2
;
Xiaoyun BIN
1
Author Information
1. School of Basic Medical Sciences, Youjiang Medical University for Nationalities， Baise 533000
2. Institute of Life Sciences, Youjiang Medical University for Nationalities， Baise 533000
- Publication Type:Journal Article
- Keywords:
SMYD5;
ribosomal methyltransferase;
hepatocellular carcinoma;
gastric adenocarcinoma;
lung cancer;
inflammatory bowel disease
- From:
Acta Universitatis Medicinalis Anhui
2026;61(4):782-788
- CountryChina
- Language:Chinese
-
Abstract:
SMYD5 is a ribosomal methyltransferase with SET and MYND structural domains， which is a member of the SMYD family and is expressed in a variety of tissues， including ovary and testis. This enzyme participates in biological processes such as gene expression regulation， cell development and differentiation， and maintenance of genomic stability through ribosomal protein methylation modification. In recent years， research on SMYD5 has increased in cancers including hepatocellular carcinoma， gastric adenocarcinoma， and lung cancer. Studies have revealed that SMYD5 exhibits high expression levels in various diseases including hepatocellular carcinoma， gastric adenocarcinoma， lung cancer， and inflammatory bowel disease， influencing the progression of these conditions. This review summarizes the role of SMYD5 in hepatocellular carcinoma， inflammatory bowel disease， and other biological functions， aiming to provide a reference for related disease research.
