New pathways in neurodegenerative disease pathogenesis： oxidative stress and ferroptosis
10.19405/j.cnki.issn1000–1492.2026.04.025
- VernacularTitle:神经退行性疾病致病新通路：氧化和铁死亡
- Author:
Yurong WANG
1
;
Jianlong YUAN
2
;
Bingchun LIU
1
Author Information
1. Laboratory of Organ Transplantation， Affiliated Hospital of Inner Mongolia Medical University， Hohhot 010050
2. Dept of Laboratory Medicine， Affiliated Hospital of Inner Mongolia Medical University， Hohhot 010050
- Publication Type:Journal Article
- Keywords:
oxidative damage;
ferroptosis;
neurodegenerative diseases;
Alzheimer's disease;
Parkinson's disease;
treatment progress
- From:
Acta Universitatis Medicinalis Anhui
2026;61(4):776-781
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative diseases such as Alzheimer's disease （AD）， Parkinson's disease （PD）， and Huntington's disease （HD） are increasingly becoming major challenges to global public health. The pathogenesis of these diseases is highly complex， with oxidative damage and ferroptosis emerging as potential core factors. Oxidative damage primarily results from the accumulation of reactive oxygen species （ROS） within cells， a process that impairs cellular function and viability. Ferroptosis， an iron-dependent form of programmed cell death， plays a crucial role in neuronal injury and apoptosis. Multiple studies indicate a significant interaction between oxidative damage and ferroptosis. This interplay not only accelerates the progression of neurodegenerative diseases but also offers new directions for potential therapeutic targets. This review systematically analyzes the mechanisms of oxidative damage and ferroptosis in various neurodegenerative diseases， evaluates current research frontiers， and explores feasible therapeutic strategies， aiming to provide new insights and perspectives for in-depth research in this field.
