Discussion on the Role of Ferroptosis in Chronic Obstructive Pulmonary Disease from the Perspective of "Qi Deficiency with Retention and Stagnation"
10.13288/j.11-2166/r.2026.11.007
- VernacularTitle:“虚气留滞”视角下铁死亡在慢性阻塞性肺疾病中的作用
- Author:
Yuchen GAO
1
;
Hongyu ZHU
1
;
Heyue XIA
1
;
Dian ZENG
1
;
Cheng YANG
2
;
Jiabing TONG
2
;
Zegeng LI
2
;
Qinjun YANG
1
Author Information
1. Anhui University of Traditional Chinese Medicine，Hefei，230038
2. First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
ferroptosis;
qi deficiency with retention and stagnation;
mitochondria;
antioxidant;
lipid peroxides
- From:
Journal of Traditional Chinese Medicine
2026;67(11):1167-1172
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a key driver of the onset and progression of chronic obstructive pulmonary disease （COPD）. By exploring the role of ferroptosis in COPD from the perspective of "qi deficiency with retention and stagnation"， it is considered that mitochondrial dysfunction and imbalanced antioxidant defenses are the microscopic manifestations of "qi deficiency"， whereas iron accumulation and lipid peroxide deposition constitute the pathological basis of "retention and stagnation". In traditional Chinese medicine （TCM）， the treatment principle is tonifying deficiency and benefiting qi， scattering retention and unblocking stagnation. Its mechanism involves improving the antioxidant system and mitochondrial function to enhance cellular resistance to ferroptosis， as well as relieving pulmonary iron overload， excessive lipid peroxidation， and inflammatory factor release to reduce the accumulation of pathological products， thereby exerting therapeutic effects on COPD.
