Research advances on trained immunity in atherosclerosis
10.19405/j.cnki.issn1000–1492.2026.03.027
- VernacularTitle:训练免疫在动脉粥样硬化中的研究进展
- Author:
Meng GUO
1
;
Jiayu CHEN
2
;
Zhen SUN
2
;
Jun XIE
1
Author Information
1. Department of Cardiology， Nanjing Drum Tower Hospital， Affiliated Hospital of Medical School， Nanjing University， Nanjing 210008
2. Department of Cardiology， The First Affiliated Hospital of Anhui Medical University， Hefei 230022
- Publication Type:Review
- Keywords:
trained immunity;
innate immune memory;
atherosclerosis;
cellular metabolic reprogramming;
epigenetic reprogramming
- From:
Acta Universitatis Medicinalis Anhui
2026;61(3):583-590
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases （CVD）， particularly atherosclerosis， represent a major global health burden. Recent studies have revealed that innate immune cells such as monocytes and macrophages can develop immune memory after an initial stimulus， a phenomenon termed “trained immunity”. Growing evidence indicates that trained immunity serves as an underlying mechanism of chronic inflammation in atherosclerotic cardiovascular diseases. This review focuses on outlining the key effector cells involved in trained immunity and their mechanisms of formation， including processes such as metabolic reprogramming and epigenetic modifications， which collectively lead to a heightened immune response upon secondary stimulation. Furthermore， this review systematically summarizes the role of trained immunity in the initiation and progression of atherosclerosis， and elaborates on various therapeutic strategies targeting trained immunity along with their application prospects.
