Systematic analysis of population pharmacokinetics of lacosamide
- VernacularTitle:拉考沙胺群体药动学研究的系统分析
- Author:
Sai CUI
1
;
Nan MENG
2
;
Huizhen WU
3
;
Yin WU
4
Author Information
1. College of Pharmacy，Hebei Medical University，Shijiazhuang 050017，China;Dept. of Pharmacy，Hebei General Hospital/Hebei Key Laboratory of Clinical Pharmacy，Shijiazhuang 050051，China
2. Dept. of Neurological Rehabilitation，Hebei General Hospital，Shijiazhuang 050051，China
3. Dept. of Pharmacy，Hebei General Hospital/Hebei Key Laboratory of Clinical Pharmacy，Shijiazhuang 050051，China
4. College of Pharmacy，Hebei Medical University，Shijiazhuang 050017，China
- Publication Type:Journal Article
- Keywords:
lacosamide;
population pharmacokinetics;
individualized administration;
influential factors;
systematic analysis
- From:
China Pharmacy
2026;37(10):1302-1306
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To systematically analyze the population pharmacokinetics （PPK） studies of lacosamide and expound the influential factors of its pharmacokinetics in different populations. METHODS PPK studies of lacosamide were collected by searching the databases， such as Web of Science， PubMed， Embase， Metasearch， CNKI， Wanfang Data and VIP， both in Chinese and English. Relevant data were extracted， and the Prediction Model Risk of Bias Assessment Tool was used to evaluate the quality of the PPK models in the included studies. RESULTS Among 8 studies ultimately included， 6 were retrospective studies and 2 were prospective studies； 5 studies involved pediatric patients. Seven studies adopted a one-compartment model， while 1 study utilized a two-compartment model. Four studies had a model quality rating of grade A， two of grade B and two of grade C， respectively. Body weight， renal function， and hepatic enzyme inducers were significant covariates influencing PPK of lacosamide. CONCLUSIONS The existing PPK studies of lacosamide are predominantly conducted in pediatric populations. Pharmacokinetic variability is mainly influenced by body weight， renal function， and hepatic enzyme inducers. However， most PPK studies have not conducted external validation， and the generalizability of the models remains to be confirmed.
