Construction of the research question system of the Guideline for the Management of Therapeutic Drug Monitoring based on modified Delphi method
- VernacularTitle:基于改良德尔菲法的《治疗药物监测管理指南》研究问题体系构建
- Author:
Rong DUAN
1
;
Liyan MIAO
2
;
Zhengxiang LI
3
Author Information
1. Pharmacy Center，Tianjin Medical University General Hospital，Tianjin 300052，China;Tianjin Center for Drug Use Monitoring and Clinical Comprehensive Evaluation，Tianjin 300052，China
2. Dept. of Pharmacy，the First Affiliated Hospital of Soochow University，Jiangsu Suzhou 215006，China
3. Pharmacy Center，Tianjin Medical University General Hospital，Tianjin 300052，China
- Publication Type:Journal Article
- Keywords:
therapeutic drug monitoring;
research questions
- From:
China Pharmacy
2026;37(10):1241-1245
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To construct a research question system of the Guideline for the Management of Therapeutic Drug Monitoring （hereinafter referred to as the Guideline ）， so as to provide the basis for the formulation of the Guideline . METHODS Based on literature research and expert interviews， the questionnaire about research questions of the Guideline was initially constructed. Through the modified Delphi method， the online questionnaire survey and expert consensus meeting were conducted among the Guideline development experts to determine the research question system of the Guideline . RESULTS A total of 59 questionnaires were distributed， and 52 valid questionnaires were collected. The positive coefficient of experts was 88.14%. The experts came from 21 provinces/autonomous regions/municipalities directly under the central government， covering multidisciplinary experts related to therapeutic drug monitoring， all of whom held senior professional titles. After one round of survey， a consensus was reached on the research questions， and a research question framework encompassing four research parts was constructed， including： indications for conducting therapeutic drug monitoring （4 first-level research questions，10 second-level research questions， 31 third-level research questions）； therapeutic drug monitoring technical process （3 first-level research questions， 9 second-level research questions， 13 third-level research questions）； result interpretation and clinical application （3 first-level research questions and 3 second-level research questions）； quality control （8 first-level research questions and 12 second-level research questions）. The importance scores for the four parts ranged from 4.71 to 4.88， with full-score rates all no less than 73.08%. The expert authori ty coefficients were all no less than 0.90， the coefficients of variation of importance scores were all no higher than 0.11， and Kendall’s W ranged from 0.464 to 0.626 （all P ＜0.05）. CONCLUSIONS The constructed research question system has high authority， scientificity， and reliability， laying a foundation for the standardized formulation of the Guideline .
