Risk factors for painful diabetic neuropathy in type 2 diabetes mellitus
10.3969/j.issn.1006-2483.2026.03.036
- VernacularTitle:2型糖尿病并发痛性神经病变的相关因素分析
- Author:
Xiaojun CAO
1
;
Mengjie TANG
1
;
Limin SHEN
1
;
Ya SHEN
1
;
Yezi SUN
1
;
Huan LU
1
Author Information
1. Department of Endocrinology, Zhangjiagang Hospital Affiliated with Soochow University, Zhangjiagang , Jiangsu 215600, China
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Painful diabetic neuropathy;
Course of disease;
Body mass index;
Fasting C-peptide
- From:
Journal of Public Health and Preventive Medicine
2026;37(3):168-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of painful diabetic neuropathy (PDN) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 269 patients with type 2 diabetes mellitus (T2DM) who were treated in the Department of Endocrinology at Zhangjiagang Hospital Affiliated to Soochow University from January 2020 to December 2024 were selected. The patients were divided into two groups: T2DM without PDN (n=190) and T2DM with PDN (n=79). The general characteristics and biochemical indicators of the two groups of patients were compared. Multivariate logistic regression was used to analyze the associated factors with PDN in T2DM. The receiver operating characteristic (ROC) curve was used to evaluate fasting C-peptide (FC-P), body mass index (BMI), and disease duration to predict the risk of PDN. Results Compared with the T2DM group without concurrent PDN, the T2DM group with concurrent PDN had a longer disease course, lower BMI, higher HDL-C, lower FC-P, and a higher proportion of diabetic retinopathy. The differences between the two groups were statistically significant (P<0.05). The results of multivariate logistic regression analysis showed that BMI, duration, and FC-P were associated factors of PDN. Conclusion BMI, duration and FC-P are associated factors of painful neuropathy complicated with type 2 diabetes.
