Effect of Helicobacter pylori infection on serum PGI, PGII and G-17 levels in elderly patients with chronic atrophic gastritis
10.3969/j.issn.1006-2483.2026.03.030
- VernacularTitle:老年慢性萎缩性胃炎患者幽门螺杆菌感染对血清PGⅠ、PGⅡ和G-17水平的影响
- Author:
Haonan XIE
1
;
Qingming WU
2
Author Information
1. Department of Gastroenterology, China Resources General Hospital, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China
2. School of Medicine, Wuhan University of Science and Technology, Wuhan , Hubei 430081, China
- Publication Type:Journal Article
- Keywords:
Elderly;
Chronic atrophic gastritis;
Pepsinogen;
Gastrin;
Helicobacter pylori
- From:
Journal of Public Health and Preventive Medicine
2026;37(3):143-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of Helicobacter pylori (Hp) infection on serum pepsinogen (PG) I, PGII and gastrin-17 (G-17) levels in elderly patients with chronic atrophic gastritis (CAG). Methods A total of 122 elderly patients with CAG and 85 elderly patients with CSG in the hospital were selected. According to Hp infection status, elderly patients with CAG were divided into CAG Hp (+) group (n=75) and CAG Hp (-) group (n=47). Another 122 healthy subjects with physical examination were enrolled as healthy group. The clinical data and levels of serum PGI, PGII and G-17 were compared among the three groups, and the risk factors affecting CAG with Hp infection were analyzed. Results There were significant differences in the proportion of Hp family infection history, the proportion of often spicy diet, the proportion of frequent dining out and levels of serum PGI, PGII and G-17 among CAG, CSG and healthy groups (P<0.05). Serum PGI and PGII in CAG Hp (+) group were lower than those in CAG Hp (-) group while G-17 level was higher (P<0.05). Binary logistic regression analysis showed that Hp family infection history, frequent dining out, serum PGI, PGII and G-17 levels were independent risk factors for Hp infection in elderly CAG (P<0.05). Conclusion Hp infection in elderly CAG patients is related to family aggregation, route of transmission and eating habits. Serum PGI, PGII and G-17 levels are influencing factors for elderly CAG with Hp infection.
