Relationship between intestinal flora imbalance and severe acute pancreatitis and intervention strategies
10.3969/j.issn.1006-2483.2026.03.028
- VernacularTitle:肠道菌群失衡与重症急性胰腺炎关系及干预策略的研究进展
- Author:
Yan WU
1
;
Yao LIU
1
Author Information
1. Department of Critical Care Medicine (ICU), West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
- Publication Type:Journal Article
- Keywords:
Severe acute pancreatitis;
Intestinal flora;
Intestinal barrier function;
Probiotics;
Multiple organ dysfunction syndrome
- From:
Journal of Public Health and Preventive Medicine
2026;37(3):133-137
- CountryChina
- Language:Chinese
-
Abstract:
Severe acute pancreatitis (SAP) is a clinically acute abdominal disease with high risk of death. In recent years, substantial evidence has demonstrated that intestinal flora imbalance plays a key role in its occurrence and development. SAP can destroy the intestinal microenvironment, mediate dysbiosis of microbiota, and lead to impaired intestinal barrier function, causing bacterial/endotoxin translocation, thereby exacerbating systemic immune inflammatory response, forming a vicious circle, and ultimately inducing multiple organ dysfunction syndrome (MODS), which seriously threatens the life of patients. With the deepening of research, some clinical intestinal flora-related intervention measures have become one of the important strategies for SAP treatment. This paper aims to explore the interaction mechanism between intestinal flora imbalance and SAP, with an emphasis on summarizing the effectiveness of current intervention strategies, including the application of probiotics, prebiotics, fecal microbiota transplantation (FMT) and other microecological regulation methods, so as to provide ideas and guidance for clinical improvement of SAP prognosis.
