Relationship between intestinal flora imbalance and pulmonary function in patients with chronic obstructive pulmonary disease
10.3969/j.issn.1006-2483.2026.03.026
- VernacularTitle:慢性阻塞性肺疾病患者肠道菌群失调与肺功能关系
- Author:
Lei CAO
1
;
Fang GAO
1
;
Jing HAO
1
;
Lei GUO
1
;
Yingjuan LIU
2
Author Information
1. >Department of Gastroenterology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China
2. Department of Respiratory Medicine, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Intestinal flora imbalance;
Pulmonary function
- From:
Journal of Public Health and Preventive Medicine
2026;37(3):123-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between intestinal flora imbalance and pulmonary function in patients with chronic obstructive pulmonary disease (COPD), and to analyze the related influencing factors. Methods A total of 310 patients with COPD who were admitted to Air Force Military Medical University Tangdu Hospital from June 2022 to December 2024 were retrospectively analyzed. Based on intestinal flora status, the enrolled patients were classified into imbalance group (n=83) and non-imbalance group (n=227). Logistic regression analysis was conducted to analyze the independent related factors of intestinal flora imbalance in COPD patients. Based on the above factors, a prediction model was constructed, and ROC curve analysis model was applied to analyze the predictive value of the model on intestinal flora imbalance. Results Logistic regression analysis revealed that age, IL-6, albumin, pulmonary function, long-term bed rest and long-term use of antibiotics were related to intestinal flora imbalance in COPD patients (all P<0.05). ROC results of the Logistic prediction model showed that the area under the curve, sensitivity, specificity and 95%CI were 0.961, 0.880, 0.996 and 0.932-0.989 respectively. Conclusion The intestinal flora imbalance in patients with COPD is closely related to lung function, age, inflammatory status, nutritional indicators, activity ability and antibiotic use.
