Serum HCV-RNA detection rate and logistic regression analysis in patients with positive hepatitis C virus IgG antibody
10.3969/j.issn.1006-2483.2026.03.025
- VernacularTitle:丙型肝炎病毒IgG抗体阳性者血清HCV-RNA检测率及logistic回归分析
- Author:
Youli HE
1
;
Yuxin FAN
1
;
Zhihong ZHANG
2
;
Yanhong GU
1
Author Information
1. Department of Laboratory, the People's Hospital of Leshan, Leshan , Sichuan 614000, China
2. Department of Intensive care unit, the People's Hospital of Leshan, Leshan , Sichuan 614000, China
- Publication Type:Journal Article
- Keywords:
Hepatitis C virus;
Immunoglobulin G antibody;
Confirmed diagnosis
- From:
Journal of Public Health and Preventive Medicine
2026;37(3):118-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate serum HCV-RNA detection rate in patients with positive hepatitis C virus (HCV) immunoglobulin G (IgG) antibody, and to analyze the related factors of HCV-RNA detection in patients with positive HCV IgG antibody by logistic regression analysis. Methods A retrospective study was conducted on 500 patients with positive HCV IgG antibody. The positive rate of HCV-RNA was counted. Logistic regression analysis was adopted to analyze the related factors of HCV-RNA detection in HCV IgG antibody positive population. Results A total of 317 patients with positive HCV-RNA detection were included in serum HCV-RNA positive group (n=317), and 183 patients with negative HCV-RNA detection were enrolled as serum HCV-RNA negative group (n=183). The diagnosis rate of HCV infection was 63.40% (317/500). Logistic regression analysis showed that abnormal levels of serum ALT, AST, GGT, TBIL, HCV IgG antibody, prothrombin time, and the presence of clinical symptoms were independently correlated with the detection of HCV-RNA in HCV IgG antibody positive individuals (P<0.05). Established 7-factor prediction models and created a nomogram. The chi-square value was 0.586, and P = 0.89 > 0.05. The ROC curve was plotted using pROC, and the area under the ROC curve was 0.912. Conclusion Among the population positive for HCV IgG antibody, the detection rate of serum HCV-RNA is high. Abnormal levels of ALT, AST, GGT, TBIL, IgG antibody, prothrombin time and clinical symptoms are the related factors for the detection of HCV-RNA. These indicators provide a reference for the clinical judgment of the real infection risk of HCV IgG positive individuals.
