Risk factors of progression to dementia within 2 years in patients with recent subcortical small infarction complicated with cognitive dysfunction
10.3969/j.issn.1006-2483.2026.03.024
- VernacularTitle:新发皮质下小梗死合并认知功能障碍患者两年内进展为痴呆的风险因素
- Author:
Lei GUO
1
;
Hui YANG
2
;
Jing YANG
3
;
Yesong LIU
1
;
Nannan ZHANG
1
;
Fengxia ZHANG
4
Author Information
1. Department of Neurology, Ward 2, Kailuan General Hospital, Tangshan 063000, Hebei, China
2. Department of Oncology, Ward 2, Kailuan General Hospital, Tangshan 063000, Hebei, China
3. Department of Nursing, Kailuan General Hospital, Tangshan 063000, Hebei, China
4. Department of Emergency, Kailuan General Hospital, Tangshan 063000, Hebei, China
- Publication Type:Journal Article
- Keywords:
Recent subcortical small infarction;
Cognitive dysfunction;
Dementia
- From:
Journal of Public Health and Preventive Medicine
2026;37(3):113-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of progression to dementia within 2 years in patients with recent subcortical small infarction (RSSI) complicated with cognitive dysfunction. Methods A total of 340 patients with RSSI complicated with cognitive dysfunction who were treated in the hospital and completed 2-year follow-up were selected from February 2021 to February 2025. According to whether the patients progressed to dementia, they were classified into dementia group (n=105) and non-dementia group (n=235). The clinical data were compared between both groups, and the independent risk factors were screened by Logistic regression analysis. Results Multivariate logistic regression analysis suggested that history of hypertension (OR=1.919), history of diabetes mellitus (OR=1.597), multiple infarctions (OR=1.455), severe white matter lesions (OR=1.595), no cognitive function training (OR=1.923), increased infarct size (OR=1.069), reduced MMSE score (OR=0.945) and increased levels of NfL (OR=1.049) and IL-6 (OR=1.038) were independent risk factors for the progression to dementia (all P<0.05). Conclusion The progression to dementia in patients with recent subcortical small infarction and cognitive dysfunction is affected by multiple factors. In clinical practice, the integration of vascular risk factors, imaging features, cognitive assessment and serum biomarkers (NfL, IL-6) helps to construct an early risk prediction model and implement targeted interventions for high-risk groups.
