Correlation and diagnostic value of fractional exhaled nitric oxide (FeNO) and blood eosinophils with lung function in patients with asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome
10.3969/j.issn.1006-2483.2026.03.023
- VernacularTitle:呼出气一氧化氮和血嗜酸性粒细胞与哮喘-慢阻肺重叠综合征患者肺功能的相关性及诊断价值
- Author:
Zhao PAN
1
;
Jinshi LIANG
1
Author Information
1. Pulmonary Function Room, Respiratory Medicine Department, Beijing Jishuitan Hospital, Beijing 100000, China
- Publication Type:Journal Article
- Keywords:
Asthma-COPD overlap syndrome;
Fractional exhaled nitric oxide (FeNO);
Blood eosinophils;
Diagnostic value
- From:
Journal of Public Health and Preventive Medicine
2026;37(3):108-112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation and diagnostic value of fractional exhaled nitric oxide (FeNO) and blood eosinophils with lung function in patients with asthma-COPD overlap syndrome (ACOS). Methods A total of 302 patients with obstructive airway disease in Beijing Jishuitan Hospital from April 2020 to April 2025 were selected as the research subjects, including 108 asthma patients, 92 COPD patients, and 102 ACOS patients. Patient data were collected and analyzed. Results There were statistically significant differences in age, smoking history, family history of asthma, FVC, FEV1, FEV1/FVC, MVV, FeNO, and blood eosinophil levels among the asthma group, COPD group, and ACOS group (P<0.05). Age and smoking history were positively correlated with the occurrence of ACOS (P<0.05), while family history of asthma, FVC, FEV1, FEV1/FVC, MVV, FeNO, and blood eosinophil levels were negatively correlated with the occurrence of ACOS (P<0.05). FeNO and blood eosinophils were not significantly correlated with lung function indicators in ACOS patients (P>0.05). FeNO had good diagnostic value in distinguishing asthma from ACOS (AUC=0.843). FeNO and blood eosinophils both had good diagnostic value in distinguishing COPD from ACOS (AUC=0.848, 0.799). Conclusion FeNO and blood eosinophils are not correlated with lung function indicators in ACOS patients. FeNO, blood eosinophils, and their combination have good diagnostic value in distinguishing asthma from ACOS, and COPD from ACOS, which have the potential to become non-invasive auxiliary diagnostic biomarkers for ACOS.
