Risk factors and predictive analysis of sarcopenia-osteoporosis in elderly patients with type 2 diabetes mellitus
10.3969/j.issn.1006-2483.2026.03.013
- VernacularTitle:老年2型糖尿病患者肌少-骨质疏松危险因素及预测分析
- Author:
Liwei ZHANG
1
;
Jian CHEN
1
;
Shujing YU
2
;
Guiling ZHENG
1
Author Information
1. Endocrine Department of Traditional Chinese Medicine, The 983rd Hospital of the PLA Joint Logistic Support Force, Tianjin 300000, China
2. Physiatry Department Dagang Traditional Chinese Medicine Hospital, Binhai New Area, Tianjin 300000, China
- Publication Type:Journal Article
- Keywords:
Osteosarcopenia;
Diabetes mellitus type 2;
Dangerous factor
- From:
Journal of Public Health and Preventive Medicine
2026;37(3):62-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the related risk factors of osteosarcopenia (OS) in elderly patients with type 2 diabetes mellitus (T2DM) and to evaluate their predictive value. Methods We selected 409 elderly patients with T2DM from our hospital between June 2021 and December 2024 as the study subjects, and divided them into an OS occurrence group and a non-occurrence group based on whether they were diagnosed with OS. Results Among the 409 elderly patients with T2DM included, 93 were diagnosed with OS, yielding a prevalence rate of 22.73%. Spearman correlation analysis revealed a significant association between lumbar spine BMD and T-scores with age, history of previous fractures, fasting plasma glucose (FPG), procollagen type I N-terminal propeptide (PINP), osteocalcin (OC), and 25-hydroxyvitamin D (25(OH)D). Gender (OR=0.193), Body Mass Index (BMI) (OR=0.254), history of previous fractures (OR=8.883), FPG (OR=0.543), Total Cholesterol (TC) (OR=3.684), High-Density Lipoprotein Cholesterol (HDL-C) (OR=86.024), PINP (OR=0.818), and OC (OR=0.526) are identified as influential factors for the occurrence of OS in elderly patients with T2DM. The combined prediction of these variables yields a sensitivity of 96.5%, a specificity of 97.8%, and an area under the curve (AUC) of 0.992 for the occurrence of OS in elderly patients with T2DM, indicating an excellent predictive performance. Conclusion The following factors—gender, BMI, history of previous fractures, FPG, TC, HDL-C, PINP, and OC—are influential in the occurrence of OS among elderly patients with T2DM. Formulating intervention measures based on these influencing factors can provide assistance in preventing and treating the occurrence of OS.
