Antibody levels of diphtheria and tetanus in healthy population in Pudong New Area, Shanghai, 2018-2024
10.3969/j.issn.1006-2483.2026.03.011
- VernacularTitle:2018—2024年上海浦东新区健康人群白喉和破伤风抗体水平监测
- Author:
Yu BAI
1
;
Dandan YANG
1
;
Wanran CHENG
1
;
Rui ZHANG
1
;
Pengfei DENG
1
;
Caoyi XUE
1
;
Laibao YANG
1
;
Yi FEI
1
Author Information
1. Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai 200136, China
- Publication Type:Journal Article
- Keywords:
Diphtheria;
Tetanus;
Vaccine;
Immunity level
- From:
Journal of Public Health and Preventive Medicine
2026;37(3):52-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the antibody levels of diphtheria and tetanus among healthy population in Shanghai Pudong New Area, and to provide a scientific basis for improving the vaccine immunization strategy. Methods Random sampling was used to select healthy people of all ages in 16 communities in Shanghai Pudong New Area from 2018 to 2024, and serum samples were collected and tested for serum anti-diphtheria and tetanus toxin IgG antibodies by enzyme-linked immunosorbent assay (ELISA) method to analyze the antibody positivity rate (≥0.1 IU/ml) and the geometric mean concentration (GMC) of antibodies. Results A total of 3 312 serum samples were included, with a male-to-female ratio of 0.76:1, and 53.77% were local residents. The seropositivity rates and geometric mean concentrations (GMC) of both diphtheria and tetanus antibodies generally declined with increasing age, but exhibited a transient rebound in the 7y-. A total of 1 175 individuals (35.48%) were seropositive for diphtheria, with a GMC of 0.054 IU/mL. For tetanus, 988 individuals (29.83%) were seropositive, with a GMC of 0.033 IU/mL. Significant differences in seropositivity rates (χ2diphtheria=950.005,χ2tetanus=1 324.393) and GMC (Hdiphtheria=1027.160,Htetanus=1 142.007) were observed among different age groups (P<0.001). Significant differences in seropositivity rates (χ2diphtheria=950.005,χ2tetanus=1324.393) and GMC (Hdiphtheria=1027.160,Htetanus=1142.007) were also found across different years (P<0.001). Conclusion The prevalence of diphtheria and tetanus antibodies in the healthy population of Pudong New Area is relatively low, particularly among adults over 20 years of age with inadequate immunization. This underscores the need to reinforce the National Immunization Program (NIP) vaccine specifications for children under 6 years of age and implement an immunization strategy for adolescents or adults against diphtheria and tetanus.
