Advances in lactic acid bacteria as recombinant protein drug delivery carrier

VernacularTitle:乳酸菌作为重组蛋白药物递送载体的研究
Author: Xufang WANG ¹ ; Yanting WANG ¹ ; Chunmeng YAO ¹ ; Bin LU ¹
Author Information

1. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
Publication Type:Reviews
Keywords: lactic acid bacteria; biological drug; delivery carrier
From: Journal of Pharmaceutical Practice and Service 2026;44(1):7-11
CountryChina
Language:Chinese
Abstract: Lactic acid bacteria (LAB) are promising candidates for live bacterial drug delivery systems owing to their safety, probiotic properties, and ability to colonize the intestinal tract. At present, most research focuses on engineering LAB as carriers for the delivery of therapeutic proteins. As model organisms equipped with a versatile set of genetic tools, LAB can be readily modified to target various diseases and yield significant therapeutic effects. LAB-based carriers offer multiple advantages, including non-invasive delivery, ease of genetic manipulation, and suitability for large-scale production. Consequently, the use of LAB as recombinant protein expression vectors has attracted extensive research interest worldwide. The foundational principles, strategies for enhancing bioavailability, genetic engineering approaches, and the current research and application status of LAB-based drug delivery systems were summarized in this paper.