Analysis of the efficacy of colistin sulfate combined with cefoperazone and sulbactam in the treatment of pan-resistant Acinetobacter baumannii intrapulmonary infection
10.12206/j.issn.2097-2024.202404093
- VernacularTitle:硫酸黏菌素联合头孢哌酮舒巴坦治疗泛耐药鲍曼不动杆菌肺内感染的疗效分析
- Author:
Pengcheng GE
1
;
Riguga SU
1
;
Tianshu REN
1
;
Dasheng DANG
1
Author Information
1. Department of Clinical Pharmacy, General Hospital of Northern Theater Command, Shenyang 110016, China.
- Publication Type:Medicine&Clinical
- Keywords:
colistin sulfate;
cefoperazone and sulbactam;
Acinetobacter baumannii;
pneumonia
- From:
Journal of Pharmaceutical Practice and Service
2026;44(5):264-267
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effecacy of colistin sulphate with cefoperazone and sulbactam in the treatment of pan-resistant Acinetobacter baumannii with the combination therapy of tigecycline with cefoperazone and baubactam. Methods By retrospective analysis, 216 ICU patients with pneumonia diagnosed with Acinetobacter baumannii from January 1，2019 to July 31，2021 were propensity matching divided into a test group （71） and a control group （145） by 1∶2. The test group was treated with colistin sulfate combined with cefoperazone and sulbactam, the control group was treated with tigecycline combined with cefoperazone and sulbactam. According to the changes of clinical symptoms and indicators before and after treatment in the two groups, the clinical response rate, bacterial clearance rate and 28 d mortality rate of the two groups were observed. Results The early clinical response and bacterial clearance of the test group were higher than that of the control group （P<0.05）; At the end of treatment, the clinical response rate and 28 d mortality were not statistically significant. Conclusion Colistin sulfate combined with cefoperazone and sulbactam was comparable to its efficacy and was superior to tigecycline combined with cefoperazone and sulbactam group in early assessment of clinical efficacy and bacterial clearance.
