Early-onset Alzheimer's disease comorbid with anti-N-methyl-D-aspartate receptor encephalitis： a case report

VernacularTitle:早发型阿尔茨海默病合并抗NMDAR脑炎1例
Author: Lisi XU ¹ ; Caixia DAI ¹ ; Shu WAN ¹ ; Man LIU ¹ ; Qingyan CAI ¹
Author Information

1. The Fourth People's Hospital of Chengdu， Chengdu 610036， China
Publication Type:Journal Article
Keywords: Anti-N-methyl-D-aspartate receptor encephalitis; Alzheimer's disease; Imaging manifestations; Neuroinflammation
From: Sichuan Mental Health 2026;39(2):171-174
CountryChina
Language:Chinese
Abstract: This article reports a case of a male patient with anti-N-methyl-D-aspartate receptor （NMDAR） encephalitis comorbid with early-onset Alzheimer's disease （AD）. The patient presented with depression， hallucinations and delusions syndrome， and cognitive impairment， and was admitted to a psychiatric hospital. Through multidisciplinary consultation， the diagnosis was confirmed based on positive biological and pathological biomarkers. The patient's symptoms improved after receiving a therapeutic regimen comprising high-dose glucocorticoid therapy and psychiatric-related treatments. Based on relevant current research findings domestically and internationally， this article reviews the pathogenesis and clinical manifestations of early-onset AD and anti-NMDAR encephalitis， in order to enhance the discrimination ability of psychiatric specialists for such patients and improve the diagnosis and treatment level. ［Funded by Medical Research Project of Chengdu City （number， 2024403）］