Application of Insect and Vine Medicinal Pairs in the Treatment of Postoperative Recurrence and Metastasis of Bladder Cancer：from the Perspective of Blood Collaterals Theory
10.13288/j.11-2166/r.2026.10.016
- VernacularTitle:血络理论视角下运用虫类、藤类药药对治疗膀胱癌术后复发转移
- Author:
Canlin WANG
1
;
Sijia LIU
2
;
Xin CHEN
1
;
Jianxin LU
1
;
Yaqiang ZHANG
1
;
Shuqi SONG
1
Author Information
1. Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing，100053
2. Tianjin Medical University
- Publication Type:Journal Article
- Keywords:
bladder cancer;
tumor recurrence;
tumor metastasis;
insect medicinals;
vine medicinals;
blood collate-rals;
stasis toxin
- From:
Journal of Traditional Chinese Medicine
2026;67(10):1120-1124
- CountryChina
- Language:Chinese
-
Abstract:
Based on the theory of blood collateral， postoperative recurrence and metastasis of bladder cancer are considered to arise primarily from the binding of stasis and toxin， which accumulate and hide within the blood collaterals. Accordingly， treatment should focus on clearing and resolving the deeply concealed stasis toxin retained in the blood collaterals. The paired use of insect and vine medicinals may exert synergistic effects by simultaneously searching out and eliminating pathogenic factors， guiding the action of herbs to the channels， and unblocking the collaterals. Drawing on clinical practice， the stasis-toxin pathogenesis of postoperative recurrence and metastasis of bladder cancer can be divided into four stages including stagnation and astringent of collateral qi， formation of fixed stasis nests， transformation of persistent stasis into toxin， and deficiency of healthy qi with lingering toxin. Accordingly， four herb pairs are proposed for each stage based on conventional treatment， which are Dilong （Pheretima）-Daxueteng （Caulis Sargentodoxae）， Shuizhi （Hirudo）-Jixueteng （Caulis Spatholobi）， Wugong （Scolopendra）-Luoshiteng （Caulis Trachelospermi）， and Quanxie （Scorpio）-Qianjinteng （stephania）. Their potential modern pharmacological mechanisms are further discussed.
