Effect of Wei's Huoxue Tongluo Formula（韦氏活血通络方）on Visual Function and Fundus Blood Flow in Treating Atrophic-Stage Non-Arteritic Anterior Ischemic Optic Neuropathy with Qi Deficiency and Blood Stasis
10.13288/j.11-2166/r.2026.10.007
- VernacularTitle:韦氏活血通络方对气虚血瘀型萎缩期非动脉炎性前部缺血性视神经病变患者视功能和眼底血流的影响
- Author:
Yan WANG
1
;
Linlin CAO
2
;
Meiling HAO
3
;
Xiaoding SHUI
1
;
Simin SONG
2
;
Kun DING
1
;
Rilong ZHOU
1
;
Yu LUO
1
;
Yize HUANG
1
;
Xiaoyu LIANG
1
;
Liang LIAO
3
Author Information
1. Beijing University of Chinese Medicine，Beijing，100029
2. Beijing Jiangong Hospital
3. Dongfang Hospital，Beijing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
non-arteritic anterior ischemic optic neuropathy;
atrophic stage;
qi deficiency and blood stasis;
optical coherence tomography angiography;
Wei's Huoxue Tongluo Formula（韦氏活血通络方）
- From:
Journal of Traditional Chinese Medicine
2026;67(10):1062-1070
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the efficacy and possible mechanism of Wei's Huoxue Tongluo Formula （韦氏活血通络方，WHTF） in treating atrophic-stage non-arteritic anterior ischemic optic neuropathy （NAION） with qi deficiency and blood stasis. MethodsA total of 82 atrophic-stage NAION patients with qi deficiency and blood stasis were randomly divided into a treatment group and a control group， with 41 cases in each group. The treatment group was given oral administration of WHTF twice a day plus acupoint injection of distilled water 2 ml at Taiyang （EX-HN5） once daily， while the control group received injection of compound anisodine injection 2 ml at Taiyang （EX-HN5） once daily and oral administration of WHTF placebo twice a day. Both groups received treatment for a course of 14 days. The best-corrected visual acuity （BCVA）， optic disc perfusion density （PD）， flux index （FI）， macular superficial PD， vascular density （VD）， and traditional Chinese medicine （TCM） syndrome scores were compared between groups before treatment and on day 7 and day 14 of treatment. Additionally， mean defect （MD） and mean sensitivity （MS） of visual fields were measured before treatment and on day 14， along with safety evaluation. ResultsAfter treatment， both groups showed significant improvement in BCVA， visual field MD and MS， and TCM syndrome scores （P＜0.05 or P＜0.01）. On day 14 of treatment， the TCM syndrome score in the treatment group was significantly lower than that in the control group （P＜0.05）. There was no significant improvement in optic disc PD and FI， and macular superficial PD and VD after treatment in either group （P＞0.05） except that on day 7 the macular superficial foveal PD in the control group was significantly better than that in the treatment group （P＜0.05）. During the treatment period， no serious adverse events occurred in either group. ConclusionWHTF can improve the visual function indicators including visual acuity and visual field， as well as TCM syndrome scores in atrophic-stage NAION patients with qi deficiency and blood stasis. It shows clinical safety， although it does not appear to have a significant effect on optic disc or macular blood flow.
