Differentiation and Treatment of Hypertension Comorbidities from the Perspective of "Constitution-Syndrome-Disease Location Correlation"
10.13288/j.11-2166/r.2026.10.006
- VernacularTitle:从“体质-证候-病位相关”探讨高血压共病的中医辨治思路
- Author:
Mengqi GAO
1
;
Anlu WANG
2
;
Hao XU
1
Author Information
1. National Clinical Research Center for Chinese Medicine Cardiology，Xiyuan Hospital，China Academy of Chinese Medical Sciences，Beijing，100091
2. Xiyuan Hospital，China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
hypertension;
comorbidity;
constitution;
syndrome;
disease location;
treating different diseases with the same therapy
- From:
Journal of Traditional Chinese Medicine
2026;67(10):1057-1061
- CountryChina
- Language:Chinese
-
Abstract:
Mainly based on the "constitution-syndrome-disease location correlation" approach， this study constructs a traditional Chinese medicine （TCM） framework for understanding hypertension comorbidities. From the perspective of shared constitutional predispositions and similar pathomechanistic characteristics， hypertension comorbidity should not be regarded as a simple aggregation of multiple diseases. Rather， it is generally rooted in biased constitutions such as yin-deficiency， qi-deficiency， yang-deficiency， phlegm-dampness， dampness-heat， and blood-stasis constitutions， accompanied by the long-term interplay of pathogenic mechanisms involving wind， fire， phlegm， stasis， and deficiency， and gradually manifests as comorbidities affecting different systems through the evolution of disease locations related to the liver， heart， spleen， and kidney. On this basis， cardiac-， cerebral-， renal-， and metabolic-related comorbidities are taken as the major categories， and their characteristics related to constitution， syndrome， and disease location are systematically summarized to clarify the correspondence between shared pathomechanisms and predominant disease locations， and to propose corresponding prevention and treatment strategies. This framework further incorporates constitution-based stratification into risk stratification for prospective intervention， and takes syndrome as the central link in developing multi-disease treatment strategies such as boosting qi and activating blood， as well as resolving phlegm and unblocking collaterals. A clinical pathway is thereby proposed， encompassing constitution assessment， syndrome differentiation， comorbidity risk stratification， integrated traditional Chinese and western medicine intervention， and follow-up feedback. This study aims to provide a reference for the theoretical development and collaborative management of hypertension comorbidities in TCM.
