Differentiation and Treatment Strategies for Pediatric IgA Vasculitis Based on the Correlation Between Blood Turbidity Theory and Oxidative Stress
10.13288/j.11-2166/r.2026.05.015
- VernacularTitle:基于血浊理论与氧化应激的相关性探讨儿童IgA血管炎的辨治思路
- Author:
Zhenhua YUAN
1
;
Yingying JIANG
1
;
Mingyang CAI
1
;
Rongxin ZHU
1
;
Xianqing REN
1
Author Information
1. Children Hospital，First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou，450003
- Publication Type:Journal Article
- Keywords:
IgA vasculitis;
oxidative stress;
blood turbidity;
childern
- From:
Journal of Traditional Chinese Medicine
2026;67(5):567-570
- CountryChina
- Language:Chinese
-
Abstract:
This paper explores the differentiation and treatment strategies for pediatric IgA vasculitis based on the correlation between blood trubidity theory and oxidative stress. It is proposed that pediatric IgA vasculitis follows an evolution of pathogenesis characterized by "deficiency of healthy qi leading to turbidity generation， accumulation of turbid toxin， and toxin damage to the collateral vessels"， which corresponds to the pathological process of oxidative stress， namely decreased antioxidant capacity with accumulation of reactive oxygen species， metabolite deposition， and endothelial cell injury. A staged treatment strategy is proposed. In the acute stage， wind-toxin invading the colla-terals and reckless movement of heat in the blood are the main manifestations， for which the treatment should focus on dispelling wind and venting pathogens， resolving toxins and unblocking the collaterals， with a modified Yinqiao Powder （银翘散） and Xijiao Dihuang Decoction （犀角地黄汤） to regulate oxidative stress burst. In the prolonged stage， intermingling of turbidity and stasis with collateral obstruction is emphasized； treatment should focus on resolving turbidity and dispelling stasis， harmonizing the blood and stabilizing the collaterals， and a modified Simiao Powder （四妙散） and Taohong Siwu Decoction （桃红四物汤） can be used to improve microcirculatory dysfunction. In the remission stage， when healthy qi remains insufficient and residual pathogens persist， treatment should focus on strengthening the root and clearing the source， reinforcing healthy qi and nourishing the collaterals， for which modified Zhibai Dihuang Pill （知柏地黄丸） and Yupingfeng Powder （玉屏风散） is suggested to rebuild the antioxidant defense system.
