Haemodialysis related renal cell carcinoma
- Author:
Hla OO
1
;
Pemasari Upali TELISINGHE
1
;
Ghazala KAFEEL
1
;
Prathibha Parampalli SUBRHAMANYA
1
;
Sowmya Tatti RAJARAM
1
Author Information
1. Department of Pathology, RIPAS Hospital, Brunei Darussalam
- Publication Type:Journal Article
- Keywords:
Acquired cystic kidney disease;
haemodialysis;
hypernephroma
- From:Brunei International Medical Journal
2013;9(2):93-96
- CountryBrunei Darussalam
- Language:English
-
Abstract:
Introduction: Development of renal cell carcinoma (RCC) is a life threatening complication of long-
term haemodialysis. Studies have shown that approximately one third or more of patients on long-term
haemodialysis of more than three years will develop acquired cystic kidney disease (ACKD), and 20-
50% of patients with ACKD, particularly with complex cysts of Bosniak types IIF, III and IV, may even-
tually transform into RCC. This study looks at the incidence of haemodialysis related RCC in Brunei Da-
russalam. Material and Methods: Cases of RCC registered in the Department of Pathology registry
from January 2000 to December 2010 were identified and retrospectively reviewed. Results: A total
number of 5,287 malignancies were reported during this period of which 74 were RCC, giving an overall
incidence of 1.4%. Out of these 74 cases, 6.8% (n=5) was found to be RCC transformed from ACKD
associated with long-term haemodialysis. There was a male preponderance (4:1), four Malay men and
one Chinese lady with a median age of 51 years (37-66) at diagnosis. The duration of haemodialysis
prior to the development of RCC ranged from 4 to 16 years. The common presenting signs and symp-
toms were cystic mass in kidney 60% (n=3), haematuria and metastatic RCC in urinary bladder 20%
(n=1), metastasis to the neck glands 20% (n=1). The right kidney was affected in four (80%) and one
on the left (20%). Conclusion: Our study showed that ACKD associated RCC accounted for 6.8% of all
RCC, and the duration to RCC development ranged from four to 16 years. There was a preponderance
in males. Radiological screening may need to be considered for patients at risk.
- Full text:202606181411075009120139293.pdf
