Clinical efficacy of repetitive transcranial magnetic stimulation at different frequencies in the treatment of multiple system atrophy
10.19845/j.cnki.zfysjjbzz.2026.0059
- VernacularTitle:不同频率重复经颅磁刺激治疗多系统萎缩的临床疗效研究
- Author:
Junmeng GUO
1
;
Yong WANG
1
Author Information
1. Department of Neurology， Jilin People’s Hospital， Jilin 132000， China
- Publication Type:Journal Article
- Keywords:
Multiple system atrophy;
Repetitive transcranial magnetic stimulation;
Primary motor cortex;
M1 region
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(4):343-348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the effective therapeutic targets of multiple system atrophy-parkinsonian type （MSA-P） based on clinical and electrophysiological assessment indices， and to investigate the clinical efficacy of low-frequency versus high-frequency repetitive transcranial magnetic stimulation （rTMS） applied to the primary motor cortex （M1 region） of the brain in patients with MSA-P. Methods A total of 40 patients with MSA-P who were diagnosed and treated in Jilin People’s Hospital from January 2023 to December 2024 were enrolled， and according to the frequency of rTMS， they were divided into low-frequency group with 20 patients and high-frequency group with 20 patients. The patients in the low-frequency group received 1 Hz rTMS over the M1 region， while those in the high-frequency group received 5 Hz rTMS over the M1 region， and clinical and electrophysiological assessments were performed for both groups at 1 week， 2 weeks， 4 weeks， and 3 months after intervention. Results After low-frequency or high-frequency rTMS was applied to the M1 region of MSA-P patients， there were no significant improvements in clinical and electrophysiological assessment indices in the low-frequency group， while the high-frequency group had significant improvements in clinical and electrophysiological assessment indices. Conclusion The primary motor cortex （M1 region） of the brain is an effective therapeutic target for MSA-P. Excitatory stimulation of the M1 region significantly improves the clinical and electrophysiological assessment indices of MSA-P， while inhibitory stimulation of the M1 region fails to achieve such improvements. This study shows that rTMS is an effective therapeutic modality for MSA-P and thus holds promise for clinical application. High-frequency rTMS over the M1 region can improve the symptoms of MSA-P and correct abnormal rhythmic activity within the cortex and related subcortical brain regions， thereby achieving a sustained therapeutic effect.
- Full text:2026061214372671824不同频率重复经颅磁刺激治疗多系统萎缩的临床疗效研究.pdf
