Possible impact of sleep fragmentation on the pathogenesis of Alzheimer disease
10.19845/j.cnki.zfysjjbzz.2026.0053
- VernacularTitle:睡眠碎片化对阿尔茨海默病发病机制的可能影响
- Author:
Huimin SHEN
1
;
Hongju ZHANG
1
Author Information
1. Zhengzhou University People’s Hospital， Henan Provincial People’s Hospital， Zhengzhou 450003， China
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Sleep fragmentation;
Amyloid-β;
tau protein;
circadian rhythm
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(4):309-312
- CountryChina
- Language:Chinese
-
Abstract:
Sleep fragmentation， characterized by disrupted nocturnal sleep，is a core manifestation of chronic insomnia and exhibits a close and complex bidirectional relationship with Alzheimer disease （AD）. On the one hand， sleep fragmentation impairs glymphatic system function， reducing the clearance efficiency of toxic metabolites such as amyloid-beta （Aβ） and tau proteins in the brain interstitial fluid， thereby acting as a promoting factor for AD. Concurrently， sleep disturbances directly dysregulate pathogenic protein dynamics，and chronic sleep deprivation exacerbates neuroinflammation and oxidative stress， worsening the AD pathological environment.On the other hand， inherent AD pathological changes further aggravate sleep fragmentation. Damage to brain regions associated with AD leads to circadian rhythm disruption and reduced non-rapid eye movement （NREM） sleep.Additionally，imbalances in neurotransmitters such as orexin and melatonin during AD progression contribute to the disintegration of the sleep-wake cycle. This review aims to explore the mutual interactions between sleep fragmentation and AD， identify current research gaps， and provide new directions for future studies.
- Full text:2026061213511311367睡眠碎片化对阿尔茨海默病发病机制的可能影响.pdf
