Research advances in exosomal miRNAs for the treatment of spinal cord injury
10.19845/j.cnki.zfysjjbzz.2026.0048
- VernacularTitle:外泌体miRNA治疗脊髓损伤的研究进展
- Author:
Ting LIANG
1
;
Liang LI
1
Author Information
1. College of Traditional Chinese Medicine， Hunan University of Chinese Medicine / Hunan Engineering Technology Research Center for Medicinal and Functional Food / Key Laboratory of TCM Heart and Lung Syndrome Differentiation ＆ Medicated Diet and Dietotherapy / Hunan Provincial Key Laboratory of TCM Diagnostics， Changsha 410208， China
- Publication Type:Journal Article
- Keywords:
Spinal cord injury;
Exosome;
miRNA;
Angiogenesis;
Axonal regeneration
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(3):275-279
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury （SCI） is a severe traumatic condition of the central nervous system for which current therapeutic strategies rarely achieve neural regeneration. In recent years， exosomes and their carried microRNA（miRNA） have demonstrated considerable potential in SCI treatment. Functioning as key mediators of intercellular communication， exosomal miRNAs coordinately regulate multiple pathophysiological processes after SCI through multiple targets and pathways.This review systematically summarizes their core mechanisms of action： （1） regulating angiogenesis via miR-126 and miR-27a-3p， and promoting the repair of the blood-spinal cord barrier via miR-210 and miR-2861， thereby improving local microcirculation； （2） precisely modulating the autophagic process via miR-421-3p and miR-374-5p to clear toxic proteins， exerting neuroprotective effects within a specific time window； and （3） facilitating axonal regeneration via miR-26a and miR-34a-5p， and modulating the glial microenvironment via miR-494 and miR-145-5p， thereby creating a favorable milieu for neural regeneration. Although exosomal miRNA therapy faces challenges in targeted delivery， standardized production， and safety evaluation， the ongoing development of engineering modification strategies and multi-omics analytics promises to transform this approach into a breakthrough strategy， bridging the gap from fundamental research to clinical application in SCI treatment.
- Full text:202606121101000318外泌体miRNA治疗脊髓损伤的研究进展.pdf
