Association between translocator protein-mediated neuroinflammation and stroke and related research advances
10.19845/j.cnki.zfysjjbzz.2026.0032
- VernacularTitle:TSPO介导的神经炎症与脑卒中的关系及相关研究进展
- Author:
Yang LI
1
;
Xiaodong ZHANG
2
Author Information
1. Taiyuan Central Hospital，Taiyuan 030009，China; Changzhi Medical College，Changzhi 046099，China
2. Taiyuan Central Hospital，Taiyuan 030009，China
- Publication Type:Journal Article
- Keywords:
Translocator protein 18 kDa;
Neuroinflammation;
Ischemic stroke;
Hemorrhagic stroke;
Microglial cells;
PET imaging;
Neuroprotection
- MeSH:
Neuroprotection
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(2):179-184
- CountryChina
- Language:Chinese
-
Abstract:
Translocator protein 18 kDa（TSPO），as a key biomarker for neuroinflammation， has attracted widespread attention in the research on the pathogenesis of stroke in recent years. Stroke is a severe neurological disease， in which neuroinflammation plays a crucial role. TSPO exhibits multiple functions in regulating the activation and polarization of microglial cells and modulating neuroprotective responses， making it an important entry point for understanding the pathological mechanism of stroke.With the continuous development of TSPO-PET imaging technology， this technology has been widely used in clinical and experimental studies， providing a powerful tool for real-time monitoring of intracerebral inflammation and evaluation of therapeutic outcomes. This article systematically reviews the research advances in TSPO in neuroinflammation associated with ischemic and hemorrhagic stroke and explores its potential neuroprotective mechanisms and application prospects，in order to provide theoretical support and research directions for the optimization and innovation of stroke treatment strategies in the future.
- Full text:2026060914310422289TSPO介导的神经炎症与脑卒中的关系及相关研究进展.pdf
