Anti-leucine-rich glioma-inactivated antibody autoimmune encephalitis： A report of two cases and literature review
10.19845/j.cnki.zfysjjbzz.2026.0030
- VernacularTitle:抗LGI1抗体自身免疫性脑炎2例报告并文献复习
- Author:
Lingling SUN
1
Author Information
1. Department of Neurology， Heze Municipal Hospital， Heze 274000， China
- Publication Type:Journal Article
- Keywords:
Leucine-rich glioma-inactivated 1 antibody;
Autoimmune encephalitis;
Limbic encephalitis;
Epilepsy
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(2):172-175
- CountryChina
- Language:Chinese
-
Abstract:
Anti-leucine-rich glioma-inactivated 1 （anti-LGI1） antibody autoimmune encephalitis is a relatively common type of limbic encephalitis，and its etiology remains unclear. It is rare for two individuals with a blood relationship to both suffer from encephalitis with positive anti-LGI1 antibodies. This article reports two sisters who lived in different counties and were diagnosed with anti-LGI1 antibody autoimmune encephalitis successively. The two sisters were diagnosed at an age of 64 and 65 years， respectively. During the course of the disease， both patients had epileptic seizures and slow response， but with different clinical manifestations. They had similar results of cranial magnetic resonance imaging and positive anti-LGI1 antibodies in cerebrospinal fluid and serum. The two patients were treated with glucocorticoid shock therapy and gamma globulin infusion during hospitalization，and both patients had a good prognosis. Recent studies have shown that anti-LGI1 antibody encephalitis is associated with genetic susceptibility.For patients with anti-LGI1 antibody encephalitis， it is necessary to inquire about family history and summarize the features of this type of disease， in order to provide better help for clinical practice.
- Full text:2026060914214695173抗LGI1抗体自身免疫性脑炎2例报告并文献复习.pdf
