Influencing factors for hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke in plateau areas
10.19845/j.cnki.zfysjjbzz.2026.0029
- VernacularTitle:中高海拔地区急性缺血性脑卒中患者静脉溶栓后出血转化的影响因素分析
- Author:
Kang DU
1
;
Juan WEN
2
Author Information
1. Department of Neurology， Qujing First People's Hospital，Qujing 655000，China
2. Department of Neurology， Hospital of Guizhou Panjiang Coal & Power Co.， Ltd.， Panzhou 553400， China
- Publication Type:Journal Article
- Keywords:
Plateau areas;
Acute ischemic stroke;
Intravenous thrombolysis;
Hemorrhagic transformation;
Risk factors
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(2):167-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influencing factors for hemorrhagic transformation （HT） after intravenous thrombolysis （IVT） in patients with acute ischemic stroke （AIS） in plateau areas. Methods A retrospective analysis was performed for AIS patients who were admitted to our hospital from February 2019 to April 2024 and received IVT with urokinase or recombinant tissue plasminogen activator， and according to the presence or absence of HT after IVT， they were divided into HT group and non-HT group. The multivariate Logistic regression analysis was used to investigate the independent risk factors for HT after IVT in AIS patients. Results A total of 437 AIS patients who underwent IVT were included in this study， among whom 45 （10.3%） experienced HT. There were significant differences between the HT group and the non-HT group in the proportion of patients with a past history of atrial fibrillation， systolic blood pressure on admission， NIHSS score before thrombolysis， neutrophil-to-lymphocyte ratio （NLR）， and blood glucose before thrombolysis （all P<0.05）. The above factors were included in a multivariate logistic regression model， and the results showed that blood glucose on admission（OR=1.122，95%CI 1.007~1.251，P<0.05） and history of atrial fibrillation （OR=3.896，95%CI 1.632~9.303，P<0.05）were independent risk factors for HT after IVT. Conclusion History of atrial fibrillation， systolic blood pressure on admission， NIHSS score before thrombolysis， blood glucose level on admission， and NLR level before treatment are influencing factors for HT after IVT in AIS patients in plateau areas， among which history of atrial fibrillation and blood glucose level before thrombolysis are independent risk factors.
- Full text:2026060914190046785中高海拔地区急性缺血性脑卒中患者静脉溶栓后出血转化的影响因素分析.pdf
